Apoptosis plays important roles in the development of the mammary gland, and its
impairment has been speculated to promote breast cancer. In mammary epithelial cells …

Apoptosis is an integral part of normal mammary gland development, differentiation, and
function. Numerous descriptive and mechanistic studies of programmed cell death pathways …

The mammary gland is a developmentally dynamic, hormone‐responsive organ that
undergoes proliferation and differentiation within the secretory epithelial compartment …

An enormous body of literature has accumulated over the past 15 years implicating
apoptosis (programmed cell death) in breast cancer cell death induced by conventional and …

A continuous cycle of cell birth and death occurs in essentially all tissues with self-renewal
capacity, with new cells being produced through cell division and older cells dying …

Introduction The control of cell number and the removal of inappropriate or damaged and
potentially dangerous cells is critical both in development and for adult tissue homeostasis …

The control of cell number and the removal of inappropriate or damaged cells is critical in
developing and adult organisms. In the mammary gland, secretory epithelial cells are …

Normal development and maintenance of tissue size is dependent on a balance between
cell proliferation and cell death. Apoptosis, or programmed cell death, plays important roles …

Dysregulation of normal programmed cell death mechanisms plays an important role in the
pathogenesis and progression of breast cancer, as well as in responses of tumors to …

A major challenge in the treatment of human breast cancer is the development of resistant
mechaims to apoptosis in cancer cells that leads to a low senstivity to therapeutic agents …