INTRODUCTION Chromatin adopts an intricate three-dimensional (3D) organization in the
nucleus that is critical for many genome processes, from gene regulation to genome …

Genomes across a wide range of eukaryotic organisms fold into higher-order chromatin
domains. Topologically associating domains (TADs) were originally discovered empirically …

The genome folds into a hierarchy of three-dimensional structures within the nucleus. At the
sub-megabase scale, chromosomes form topologically associating domains (TADs) …

It is now widely appreciated that the spatial organization of the genome is nonrandom, and
its complex 3D folding has important consequences for many genome processes. Recent …

Chromosomes in proliferating metazoan cells undergo marked structural metamorphoses
every cell cycle, alternating between highly condensed mitotic structures that facilitate …

The spatial organization of the genome is intimately linked to its biological function, yet our
understanding of higher order genomic structure is coarse, fragmented and incomplete. In …

A current question in the high-order organization of chromatin is whether topologically
associating domains (TADs) are distinct from other hierarchical chromatin domains …

INTRODUCTION Genomes are spatially organized across length scales from single base
pairs to whole chromosomes. This organization is thought to regulate gene expression and …

The non-random three-dimensional organization of genomes is critical for many cellular
processes. Recently, analyses of genome-wide chromatin packing in the model dicot plant …

In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …