Prevention of heartworm disease caused by Dirofilaria immitis in domestic dogs and cats
relies on a single drug class, the macrocyclic lactones (MLs). Recently, it has been …

Macrocyclic lactone (ML) endectocides are used as chemoprophylaxis for heartworm
infection (Dirofilaria immitis) in dogs and cats. Claims of loss of efficacy (LOE) of ML …

Abstract Background Strains of Dirofilaria immitis suspected of lack of efficacy (LOE) to
macrocyclic lactone (ML) preventive drugs have been increasingly reported in dogs by …

Anthelmintics of the macrocyclic lactone (ML) drug class are widely used as preventives
against the canine heartworm (Dirofilaria immitis). Over the past several years, however …

In order to provide a background to current concerns relative to the possible resistance of
heartworms to macrocyclic lactones, this review summarizes various studies in which lack of …

For more than 20 years, anthelmintics of the macrocyclic lactone (ML) drug class have been
widely and effectively used as preventives against the canine heartworm, Dirofilaria immitis …

Dirofilaria immitis infection is one of the most severe parasitic diseases in dogs. Prevention
is achieved by the administration of drugs containing macrocyclic lactones (MLs). These …

Heartworm disease, caused by Dirofilaria immitis, can be lethal in dogs and cats. It is
transmitted by mosquitoes, and occurs in many parts of the world. Prevention relies on …

Reports of loss-of-efficacy (LOE) events in dogs infected with Dirofilaria immitis despite
adherence to accepted prophylaxis regimens with a macrocyclic lactone anthelmintic are …

Prophylaxis with macrocyclic lactone (ML) endectocides is the primary strategy for
heartworm control. Recent evidence has confirmed that ML-resistant Dirofilaria immitis …