Abstract 1 Twenty-nine dogs were given digoxin (0.25 mg) by mouth twice daily for eight
days. Some of them (group 1) also received diuretics and others (group 2) a …

Abstract 1 The tendency of a given oral dose of digoxin to induce cardiac dysrhythmia was
determined indirectly at various times after its administration to eight conscious dogs by …

Abstract 1 The time course of myocardial uptake of digoxin, increase in contractility and
changes in myocardial potassium concentration was studied for 90 min following an …

Results Of the io8 subjects studied, 54 were men and 54 were women; 22 (20'4%) were
found to have clinical or electrocardiographic evidence of digoxin toxicity. The results are …

ABSTRACT MARcus, FRANK I., Lsr NIMM0, GEETA G. KAPADIA AND C4uu GOLDSMITH:
The effect of acute hypokalemia on the myocardial concentration and body distribution of …

The measurement of digoxin in plasma or serum using the technique of radioimmunoassay
is both rapid and reliable, and a relationship between the electro-cardiographic signs …

Serum and myocardial digoxin levels were studied in 18 patients who came to autopsy. An
independent analysis of electrocardiograms prior to death was made to ascertain the …

Digoxin was infused intravenously 27.5 μg/min. to guinea pigs. By means of the ECG doses
of digoxin needed to cause ventricular extrasystoles (VES), ventricular fibrillation (VF), and …

Serum digoxin estimations were done in 98 patients receiving digoxin for heart failure of
varied aetiology. Digoxin toxicity or the lack of it was determined on the basin of established …

Of the several glycosides available for treating heart disease, digoxin has found most favour
in Britain. All these drugs have a narrow therapeutic index, and intoxication occurs in 10 …