[PDF][PDF] Genomic biomarkers for chronic kidney disease: the first step towards personalized medicine?

JY Cao, LT Zhou, BC Liu - Journal of Translational …, 2019 - pdfs.semanticscholar.org
With the prevalence of end stage renal disease steadily increasing, chronic kidney disease
(CKD) represents an impending public healthcare challenge. Classical diagnostic …

Genomic biomarkers for chronic kidney disease

W Ju, S Smith, M Kretzler - Translational Research, 2012 - Elsevier
Chronic kidney disease (CKD) remains a major challenge in nephrology and for public
health care, affecting 14% to 15% of the adult US population and consuming significant …

[HTML][HTML] Genomic approaches in the search for molecular biomarkers in chronic kidney disease

M Cañadas-Garre, K Anderson, J McGoldrick… - Journal of translational …, 2018 - Springer
Background Chronic kidney disease (CKD) is recognised as a global public health problem,
more prevalent in older persons and associated with multiple co-morbidities. Diabetes …

Personalized medicine in nephrology: a novel approach or just good medicine?

MW Taal - Current Opinion in Nephrology and Hypertension, 2018 - journals.lww.com
The era of 'evidence-based medicine'emphasized the need for robust evidence to ensure
that treatments afford benefit with limited or acceptable levels of harm, but neglected …

[HTML][HTML] The use of 'omics for diagnosing and predicting progression of chronic kidney disease: A scoping review

MA Govender, JT Brandenburg, J Fabian… - Frontiers in …, 2021 - frontiersin.org
Globally, chronic kidney disease (CKD) contributes substantial morbidity and mortality.
Recently, various 'omics platforms have provided insight into the molecular basis of kidney …

Integrated multi-omics approaches to improve classification of chronic kidney disease

S Eddy, LH Mariani, M Kretzler - Nature Reviews Nephrology, 2020 - nature.com
Chronic kidney diseases (CKDs) are currently classified according to their clinical features,
associated comorbidities and pattern of injury on biopsy. Even within a given classification …

[HTML][HTML] Precision medicine comes of age in nephrology: identification of novel biomarkers and therapeutic targets for chronic kidney disease

CM Wyatt, D Schlondorff - Kidney International, 2016 - Elsevier
The goal of “precision medicine” is to characterize diseases based on the underlying
molecular biology, in order to identify specific biomarkers and therapeutic targets that will …

Molecular stratification of chronic kidney disease

A Reznichenko, V Nair, S Eddy, M Tomilo, T Slidel… - medRxiv, 2021 - medrxiv.org
Current classification of chronic kidney disease (CKD) into stages based on the indirect
measures of kidney functional state, estimated glomerular filtration rate and albuminuria, is …

Developments in renal pharmacogenomics and applications in chronic kidney disease

A Padullés, I Rama, I Llaudó… - Pharmacogenomics and …, 2014 - Taylor & Francis
Chronic kidney disease (CKD) has shown an increasing prevalence in the last century. CKD
encompasses a poor prognosis related to a remarkable number of comorbidities, and many …

How can genetics and epigenetics help the nephrologist improve the diagnosis and treatment of chronic kidney disease patients?

A Witasp, TJ Ekström, M Schalling… - Nephrology Dialysis …, 2014 - academic.oup.com
Discovery of novel improved tools for diagnosis, prevention and therapy of chronic kidney
disease (CKD) is an important task for the nephrology community and it is likely that …