In addition to its well-documented involvement in mineral homeostasis, vitamin D seems to
have broad effects on human health that go beyond the skeletal system. Prominent among …

There is an increasing interest in the role of vitamin D as a potential treatment for a number
of disparate diseases. In addition to its role in calcium homeostasis, vitamin D has a plethora …

The discovery of the vitamin D receptor (VDR) in the cells of the immune system and the fact
that activated dendritic cells produce the vitamin D hormone suggested that vitamin D could …

Vitamin D-deficiency has been linked to inflammatory diseases including rheumatoid
arthritis (RA). Studies to date have focused on the impact of serum 25-hydroxyvitamin D3 (25 …

Vitamin D is frequently prescribed by rheumatologists to prevent and treat osteoporosis.
Several observations have shown that vitamin D inhibits proinflammatory processes by …

Vitamin D has been reported to influence physiological systems that extend far beyond its
established functions in calcium and bone homeostasis. Prominent amongst these are the …

Background The major circulating “storage” metabolite of the secosteroid vitamin D, 25-
hydroxyvitamin D (25 [OH] D), is frequently used as an objective biomarker of vitamin D …

Vitamin D is classified as a secosteroid in which one of the rings has been broken, in this
case by ultraviolet B sunlight, and the main source of vitamin D is de novo synthesis in the …

Objectives: Vitamin D deficiency has been implicated in the pathogenesis of autoimmune
diseases, such as diabetes mellitus type 1 and multiple sclerosis. Reduced vitamin D intake …

Vitamin D plays an important role in maintaining a healthy mineralized skeleton. It is also
considered an immunomodulatory agent that regulates innate and adaptive immune …