DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in
regulating gene expression. The epigenetic component is strongly involved in aging-bone …

DNA methylation in eukaryotes invokes heritable alterations of the of the cytosine base in
DNA without changing the underlying genomic DNA sequence. DNA methylationmay be …

Bone is a complex connective tissue characterized by a calcified extracellular matrix. This
mineralized matrix is constantly being formed and resorbed throughout life, allowing the …

Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors
are strongly associated with its development; however, recently it has been observed that …

OBJECTIVE: To review the current knowledge of the mechanism of DNA methylation, its
association with transcriptional silencing, possible mechanisms of hyper-and …

Osteoporosis is one of the most common metabolic skeletal diseases, which affects more
than 200 million people worldwide, especially elderly and postmenopausal women. One of …

Osteoporosis is an age‐related metabolic bone disease. Hence, osteoporotic patients might
suffer from molecular features of accelerated aging, which is generally reflected by specific …

DNA methylation is an important epigenetic modification that contributes to the lineage
commitment and specific functions of different cell types. In this study, we compared …

Aging is a major risk factor for individuals' health problems. Moreover, environmental signals
have a widespread influence on the aging process. Epigenetic modification, eg DNA …

Bone diseases such as osteoarthritis, osteoporosis, and bone tumor present a severe public
health problem. Osteogenic differentiation is a complex process associated with the …