Aberrant phosphorylation of tau is associated with a number of neurodegenerative diseases,
including Alzheimer's disease (AD). The molecular mechanisms by which tau …

Multisite hyperphosphorylation of tau has been implicated in the pathogenesis of
neurodegenerative diseases including Alzheimer's disease (AD). However, the …

Tau neuronal protein has a central role in neurodegeneration and is implicated in Alzheimer
disease development. Abnormal phosphorylation of Tau impairs its interaction with other …

Deposition of extensively hyperphosphorylated tau in specific brain cells is a clear
pathological hallmark in Alzheimer's disease and a number of other neurodegenerative …

Abnormal phosphorylation of the microtubule-associated protein tau is observed in many
neurodegenerative diseases, including Alzheimer's disease (AD). AD-related …

Hyperphosphorylation of tau is a hallmark of Alzheimer's disease and other tauopathies.
Although the mechanisms underlying hyperphosphorylation are not fully understood …

In Alzheimer disease (AD), the microtubule-associated protein tau is found
hyperphosphorylated in paired helical filaments. Among many phosphorylated sites in tau …

Abnormal accumulation of the microtubule-interacting protein tau is associated with
neurodegenerative diseases including Alzheimer's disease (AD). β-amyloid (Aβ) lies …

The predominant brain microtubule-associated proteins MAP2 and tau play a critical role in
microtubule cytoskeletal organization and function. We have previously reported that …

Hyperphosphorylation of tau at multiple sites has been implicated in the formation of
neurofibrillary tangles in Alzheimer's disease; however, the relationship between toxicity and …