[HTML][HTML] The IL-17 family of cytokines in health and disease

MJ McGeachy, DJ Cua, SL Gaffen - Immunity, 2019 - cell.com
The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A
through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th …

[HTML][HTML] The IL-17 family in diseases: from bench to bedside

L Huangfu, R Li, Y Huang, S Wang - Signal Transduction and Targeted …, 2023 - nature.com
Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

IL-17 in the pathogenesis of disease: good intentions gone awry

S Majumder, MJ McGeachy - Annual review of immunology, 2021 - annualreviews.org
The IL-17 family is an evolutionarily old cytokine family consisting of six members (IL-17A
through IL-17F). IL-17 family cytokines signal through heterodimeric receptors that include …

IL-17 signaling: the yin and the yang

N Amatya, AV Garg, SL Gaffen - Trends in immunology, 2017 - cell.com
Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While
the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL …

IL-17 cytokines in immunity and inflammation

W Jin, C Dong - Emerging microbes & infections, 2013 - Taylor & Francis
Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in
the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper …

The IL-17 family cytokines in immunity and disease

R Pappu, V Ramirez-Carrozzi, N Ota… - Journal of clinical …, 2010 - Springer
Introduction Accumulating evidence suggests that the interleukin (IL)-17 cytokines are major
players in the immune response to foreign pathogens. In addition, the pathogeneses of a …

[HTML][HTML] Functional specialization of interleukin-17 family members

Y Iwakura, H Ishigame, S Saijo, S Nakae - Immunity, 2011 - cell.com
Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17)
cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F …

Interleukin-17 as a drug target in human disease

S Ivanov, A Lindén - Trends in Pharmacological Sciences, 2009 - cell.com
Interleukin (IL)-17 (now synonymous with IL-17A) is an archetype molecule for an entire
family of IL-17 cytokines. Currently believed to be produced mainly by a specific subset of …

[HTML][HTML] Interleukin-17 family members and inflammation

JK Kolls, A Lindén - Immunity, 2004 - cell.com
IL-17A was cloned more than 10 years ago and six IL-17 family members (IL-17A-F) have
subsequently been described. IL-17A is largely produced by activated memory T …

IL-17 family member cytokines: regulation and function in innate immunity

JM Reynolds, P Angkasekwinai, C Dong - Cytokine & growth factor reviews, 2010 - Elsevier
Recently, the IL-17 family member cytokines have become prominent subjects of
investigation. IL-17 (IL-17A) is the best-described member of this family where its production …