Plasma methylphenidate concentrations in youths treated with high-dose osmotic release oral system formulation

JR Stevens, RA George, S Fusillo, TA Stern… - Journal of Child and …, 2010 - liebertpub.com
Background: Children and adolescents are being treated increasingly for attention-
deficit/hyperactivity disorder (ADHD) with a variety of stimulants in higher than Food and …

Single-and multiple-dose pharmacokinetics of methylphenidate administered as methylphenidate transdermal system or osmotic-release oral system methylphenidate …

D Pierce, A Katic, M Buckwalter… - Journal of clinical …, 2010 - journals.lww.com
This was a 1-month, multicenter, open-label, randomized study to determine single-and
multiple-dose pharmacokinetics of d, l-methylphenidate (MPH) after MPH transdermal …

Remission in children and adolescents diagnosed with attention-deficit/hyperactivity disorder via an effective and tolerable titration scheme for osmotic release oral …

WJ Chou, SJ Chen, YS Chen, HY Liang… - Journal of Child and …, 2012 - liebertpub.com
Objectives: The purpose of this study was to identify the optimal dose of osmotic release oral
system methylphenidate (OROS-MPH) using a dosage forced-titration scheme to achieve …

Efficacy of two long-acting methylphenidate formulations in children with attention-deficit/hyperactivity disorder in a laboratory classroom setting

R Silva, R Muniz, LK Pestreich, M Brams… - Journal of Child & …, 2005 - liebertpub.com
Objective: The aim of this study was to compare efficacy and safety of two long-acting
formulations of methylphenidate (MPH) for attention-deficit/hyperactivity disorder (ADHD) in …

A Pharmacokinetic Study of Methylphenidate Hydrochloride Multilayer Extended-Release Capsules (Aptensio XR®) in Preschool-Aged Children with Attention-Deficit …

AL Adjei, I Chaudhary, SH Kollins, A Padilla - Pediatric Drugs, 2020 - Springer
Objective This was a single-dose, one-period, multicenter, pharmacokinetic (PK) study to
evaluate the PK of methylphenidate (MPH) hydrochloride multilayer extended-release …

An open-label, randomized, active-controlled equivalent trial of osmotic release oral system methylphenidate in children with attention-deficit/hyperactivity disorder in …

SSF Gau, HY Shen, WT Soong… - Journal of Child & …, 2006 - liebertpub.com
This study examined the efficacy and safety of osmotic release oral system methylphenidate
(OROS MPH) as compared with immediate-release MPH (IR MPH) in children with attention …

Multisite controlled study of OROS methylphenidate in the treatment of adolescents with attention-deficit/hyperactivity disorder

TE Wilens, K McBurnett, O Bukstein… - … of Pediatrics & …, 2006 - jamanetwork.com
Background Despite the persistence of attention-deficit/hyperactivity disorder (ADHD) into
adolescence, little is known about the efficacy and tolerability of stimulant medications in this …

Subjective effects, misuse, and adverse effects of osmotic-release methylphenidate treatment in adolescent substance abusers with attention-deficit/hyperactivity …

TM Winhusen, DF Lewis, PD Riggs… - Journal of child and …, 2011 - liebertpub.com
Objective: Psychostimulants are effective treatments for attention-deficit/hyperactivity
disorder (ADHD) but may be associated with euphoric effects, misuse/diversion, and …

Pharmacokinetics of methylphenidate in preschoolers with attention-deficit/hyperactivity disorder

SB Wigal, S Gupta, L Greenhill, K Posner… - Journal of Child and …, 2007 - liebertpub.com
Objective: The aim of this study was to compare the pharmacokinetics of immediate-release
methylphenidate (MPH) in preschool and school-aged children with attention …

A single-dose, single-period pharmacokinetic assessment of an extended-release orally disintegrating tablet of methylphenidate in children and adolescents with …

A Childress, J Newcorn, JG Stark… - Journal of Child and …, 2016 - liebertpub.com
Objective: To determine the pharmacokinetic (PK) profile of a proprietary formulation of
methylphenidate (MPH) in children and adolescents with attention-deficit/hyperactivity …