Several types of immune cells possess pattern recognition receptors (PRR) that can
distinguish prokaryotic DNA from vertebrate DNA by detecting unmethylated CpG …

Certain vertebrate immune cells have evolved receptors that detect the presence of
pathogen DNA based on its content of unmethylated CpG dinucleotides in particular base …

Immune stimulation has been widely recognized as an undesirable side effect of certain
antisense oligodeoxynucleotides (ODN) which can interfere with their therapeutic …

Bacterial DNA and oligonucleotides containing unmethylated CpG dinucleotides (CpG DNA)
can stimulate immune responses and have potential for use as novel agents to enhance …

The genomes of bacterial and viral DNA contain a much higher frequency of unmethylated
CpG dinucleotides than those of vertebrates. This difference in genome structure allows the …

Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated “CpG
motifs” stimulate an innate immune response characterized by the production of cytokines …

Vertebrate immune systems have evolved the ability to detect and be activated by most
microbial and viral DNAs by virtue of their content of unmethylated 'CpG motifs', which are …

Bacterial DNA with CpG motifs can efficiently stimulate the vertebrate immune system. Thus,
synthetic oligodeoxynucleotides that contain such CpG motifs (CpG-ODN) are currently used …

Bacterial DNA and synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG
motifs stimulate the mammalian immune system to mount a rapid innate immune response …

Bacterial DNA differs from vertebrate DNA in having a much higher content of unmethylated
CpG dinucleotides, in particular, base contexts that are termed 'CpG motifs'. The vertebrate …