Huntington's disease (HD) clinical manifestations begin insidiously and are progressively
incapacitating. Symptomatic therapies, in particular dopamine blockers and neuroleptics …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …

Highlights•Post-transcriptional gene silencing has shown preclinical benefits for the
treatment of HD.•Specific design/synthesis of oligonucleotides is essential for on-target …

Introduction Huntington's disease is a neurodegenerative disease that is characterized by
motor dysfunction, behavioral/psychiatric symptoms, and cognitive impairment. Because of …

Huntington's disease (HD) is a monogenic neurodegenerative disorder that presents with
progressive motor, behavior, and cognitive symptoms leading to early disability and …

Abstract Purpose of Review This article describes and discusses new potential disease-
modifying therapies for Huntington's disease that are currently in human clinical trials as well …

Huntington's disease (HD) is a progressive neurological disease that is inherited in an
autosomal fashion. The cause of disease pathology is an expansion of cytosine-adenine …

Huntington's disease (HD) is a devastating genetic disorder. Despite the absence of
effective therapy, there has been an explosion in interest for developing treatment strategies …

Neurodegenerative movement disorders, such as Huntington's disease (HD), share a
progressive and relentless course with increasing motor disability, linked with …

Huntington's disease (HD) is a fatal autosomal-dominant disorder involving progressive
motor, cognitive and psychiatric symptoms. HD is one of a large family of neurodegenerative …