Pathogenesis of membranous nephropathy: a new paradigm in evolution

RJ Glassock - New Insights into Glomerulonephritis, 2013 - karger.com
Membranous nephropathy (MN) has been recognized as a distinct morphological entity for
over 50 years, but it is only recently that the underlying pathogenesis of the primary form of …

Membranous nephropathy: a journey from bench to bedside

JM Francis, LH Beck Jr, DJ Salant - American Journal of Kidney Diseases, 2016 - Elsevier
Lessons from an animal model that faithfully resembles human membranous nephropathy
(MN) have informed our understanding of the pathogenesis of this organ-specific …

[HTML][HTML] How times have changed! A cornucopia of antigens for membranous nephropathy

TN Caza, LF Al-Rabadi, LH Beck Jr - Frontiers in Immunology, 2021 - frontiersin.org
The identification of the major target antigen phospholipase A2 receptor (PLA2R) in the
majority of primary (idiopathic) cases of membranous nephropathy (MN) has been followed …

Membranous nephropathy: new pathogenic mechanisms and their clinical implications

E Hoxha, L Reinhard, RAK Stahl - Nature Reviews Nephrology, 2022 - nature.com
Membranous nephropathy (MN) is characterized histomorphologically by the presence of
immune deposits in the subepithelial space of the glomerular filtration barrier; its clinical …

[HTML][HTML] Membranous nephropathy: from models to man

LH Beck, DJ Salant - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
As recently as 2002, most cases of primary membranous nephropathy (MN), a relatively
common cause of nephrotic syndrome in adults, were considered idiopathic. We now …

Immunology of membranous nephropathy: from animal models to humans

RA Sinico, N Mezzina, B Trezzi… - Clinical & …, 2016 - academic.oup.com
Membranous nephropathy (MN), the leading cause of nephrotic syndrome in adults, is
characterized by the deposition of subepithelial immune deposits that consist mainly of …

A conceptual framework linking immunology, pathology, and clinical features in primary membranous nephropathy

GB Lerner, S Virmani, JM Henderson, JM Francis… - Kidney International, 2021 - Elsevier
Primary membranous nephropathy is a leading cause of adult nephrotic syndrome. The field
took a major step forward with the identification of phospholipase A2 receptor (PLA2R) as a …

Pathogenesis of membranous nephropathy: recent advances and future challenges

P Ronco, H Debiec - Nature Reviews Nephrology, 2012 - nature.com
Over the past few years, considerable advances have been made in our understanding of
the molecular pathomechanisms of human membranous nephropathy, inspired by studies of …

Anti-phospholipase A2 receptor antibodies and the pathogenesis of membranous nephropathy

P Ronco, H Debiec - Nephron Clinical Practice, 2015 - karger.com
Since the early 2000s, considerable advances have been achieved in the understanding of
molecular pathomechanisms of human membranous nephropathy (MN), inspired by studies …

Molecular pathogenesis of membranous nephropathy

P Ronco, H Debiec - Annual Review of Pathology: Mechanisms …, 2020 - annualreviews.org
Membranous nephropathy is a noninflammatory autoimmune disease of the kidney
glomerulus, characterized by the formation of immune deposits, complement-mediated …