Handling the hurdles on the way to anti-tuberculosis drug development

PF Dalberto, EV De Souza, BL Abbadi… - Frontiers in …, 2020 - frontiersin.org
The global epidemic of tuberculosis (TB) imposes a sustained epidemiologic vigilance and
investments in research by governments. Mycobacterium tuberculosis, the main causative …

Improving the tuberculosis drug development pipeline

D Evangelopoulos, TD McHugh - Chemical Biology & Drug …, 2015 - Wiley Online Library
Mycobacterium tuberculosis is considered one of the most successful pathogens and
multidrug‐resistant tuberculosis, a disease that urgently requires new chemical entities to be …

Tuberculosis drug discovery: challenges and new horizons

GFS Fernandes, AM Thompson… - Journal of Medicinal …, 2022 - ACS Publications
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

Current status and research strategies in tuberculosis drug development: miniperspective

LG Dover, GD Coxon - Journal of medicinal Chemistry, 2011 - ACS Publications
In this Miniperspective we broadly cover the recent developments and strategies that are
being adopted globally in the battle to urgently discover and develop new drugs to treat …

[HTML][HTML] The quest for the holy grail: new antitubercular chemical entities, targets and strategies

S Huszar, K Chibale, V Singh - Drug Discovery Today, 2020 - Elsevier
Highlights•In 2018 1.2 million people died of tuberculosis.•The ideal drug candidate should
be active against replicating and nonreplicating Mycobacterium tuberculosis.•New drug …

Challenges and opportunities in developing novel drugs for TB

T Kaneko, C Cooper, K Mdluli - Future Medicinal Chemistry, 2011 - Taylor & Francis
Mycobacterium tuberculosis is a difficult pathogen to combat and the first-line drugs currently
in use are 40–60 years old. The need for new TB drugs is urgent, but the time to identify …

Key targets and relevant inhibitors for the drug discovery of tuberculosis

X Xiong, Z Xu, Z Yang, Y Liu, D Wang… - Current Drug …, 2013 - ingentaconnect.com
Tuberculosis (TB) is an infectious disease caused by the pathogen Mycobacterium
tuberculosis (M. tuberculosis), killing about two million people worldwide each year. An …

Harnessing biological insight to accelerate tuberculosis drug discovery

TJ de Wet, DF Warner, V Mizrahi - Accounts of Chemical Research, 2019 - ACS Publications
Conspectus Tuberculosis (TB) is the leading cause of mortality globally resulting from an
infectious disease, killing almost 1.6 million people annually and accounting for …

Advances in key drug target identification and new drug development for tuberculosis

J Mi, W Gong, X Wu - BioMed Research International, 2022 - Wiley Online Library
Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of
drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control …

Filling the pipeline-new drugs for an old disease

M Stehr, AA Elamin, M Singh - Current topics in medicinal …, 2014 - ingentaconnect.com
Tuberculosis is a major global health problem. In the middle of the last century several
laboratories identified, developed and synthesized several substances which were active …