Phosphorylation regulates both normal and pathological Tau functioning. This microtubule-
associated protein plays a role in the organization and integrity of the neuronal cytoskeleton …

Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …

Proline-directed kinases such as the mitogen-activated protein (MAP) kinases, cyclin-
dependent protein kinase 5 (CDK5) and glycogen synthase 3 (GSK3) have been implicated …

Introduction Abnormal phosphorylation of tau is a feature of Alzheimer's disease (AD), which
develops prematurely in Down syndrome (DS) patients. Cognitive impairment is also …

Tauopathies are a broad set of neurodegenerative dementias characterized by the
aggregation of Tau protein. Activated microglia and elevated levels of pro-inflammatory …

Alzheimer's disease (AD) is a neurogenetic condition that affects the processes via which
the brain functions. Major observable hallmarks of AD are accumulated clusters of proteins …

Hyperphosphorylation and accumulation of tau in neurons (and glial cells) is one the main
pathologic hallmarks in Alzheimer's disease (AD) and other tauopathies, including Pick's …

Background An accumulating body of evidence is consistent with the hypothesis that
excessive or prolonged increases in proinflammatory cytokine production by activated glia is …

Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …

Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second
largest incidence rate among all other neurodegenerative disorders barring Alzheimer's …