Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range
of cellular stresses as well as in response to inflammatory cytokines. There are four …

Aberrant phosphorylation of tau is associated with a number of neurodegenerative diseases,
including Alzheimer's disease (AD). The molecular mechanisms by which tau …

Neurofibrillary tangles (NFTs) are the pathological hallmark of neurodegenerative diseases
commonly known as tauopathies. NFTs result from the intracellular aggregation of …

p38 MAPK family consists of four isoform proteins (α, β, γ, and δ) that are activated by the
same stimuli, but the information about how these proteins act together to yield a biological …

Acute treatment with kainate 30mg/kg (KA) produced behavioral alterations and reactive
gliosis. However, it did not produce major death of mouse hippocampal neurons, indicating …

Alzheimer's disease is the most common form of dementia. Abnormal hyperphosphorylation
of Microtubule associated protein tau (MAPT) is one of the hallmarks of Alzheimer's disease …

Among the long list of age-related complications, Alzheimer's disease (AD) has the most
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …

The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular
signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), with each MAPK …

Mitogen-activated protein kinases (such as Erk1/2) regulate phosphorylation of the
microtubule-associated protein tau and processing of the amyloid protein β, both events …

The two classical pathological hallmarks of Alzheimer's disease are deposits of aggregated
β-amyloid (Aβ) peptide and neurofibrillary tangles composed of hyperphosphorylated tau …