Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain
SJ Liu, JY Zhang, HL Li, ZY Fang, Q Wang… - Journal of Biological …, 2004 - ASBMB
Microtubule-associated protein tau is abnormally hyperphosphorylated in Alzheimer's
disease (AD) and other tauopathies and is believed to lead to neurodegeneration in this …
disease (AD) and other tauopathies and is believed to lead to neurodegeneration in this …
p38 MAPK signalling cascades in inflammatory disease
E Herlaar, Z Brown - Molecular medicine today, 1999 - cell.com
Inflammatory mediators released during acute and chronic diseases activate multiple
intracellular signalling cascades including the mitogen-activated protein kinase (MAPK) …
intracellular signalling cascades including the mitogen-activated protein kinase (MAPK) …
[HTML][HTML] Non-classical p38 map kinase functions: cell cycle checkpoints and survival
TM Thornton, M Rincon - International journal of biological …, 2009 - ncbi.nlm.nih.gov
The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress
stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the …
stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the …
Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease
Introduction: Alzheimer's disease (AD) is a major public health problem in modern society
and as yet, other than a few symptomatic drugs, there is no disease-modifying treatment for …
and as yet, other than a few symptomatic drugs, there is no disease-modifying treatment for …
[HTML][HTML] An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling
The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …
PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3β
W Qian, J Shi, X Yin, K Iqbal… - Journal of …, 2010 - content.iospress.com
Abnormal hyperphosphorylation of tau appears to be crucial in neurofibrillary degeneration
in Alzheimer's disease (AD). Previous studies suggest that a down-regulation of protein …
in Alzheimer's disease (AD). Previous studies suggest that a down-regulation of protein …
MAPKs as mediators of cell fate determination: an approach to neurodegenerative diseases
Neurodegenerative diseases do affect glial or neuronal cells in both the peripheral and
central nervous systems. Although they are characterized by different features and a …
central nervous systems. Although they are characterized by different features and a …
MAPK p38 regulates transcriptional activity of NF-κB in primary human astrocytes via acetylation of p65
MAPK-p38 plays an important role in inflammation. Several studies have shown that
blocking p38 activity attenuates the transcriptional activity of the proinflammatory …
blocking p38 activity attenuates the transcriptional activity of the proinflammatory …
Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3β and cyclin-dependent kinase 5 inhibition and results in tau …
Hyperphosphorylated tau is the major component of paired helical filaments in
neurofibrillary tangles found in Alzheimer's disease (AD) brain. Starvation of adult mice …
neurofibrillary tangles found in Alzheimer's disease (AD) brain. Starvation of adult mice …
JNK: a stress-activated protein kinase therapeutic strategies and involvement in Alzheimer's and various neurodegenerative abnormalities
The c-Jun N-terminal kinase (JNKs), also known as stress-activated protein kinase (SAPK),
is one such family of multifunctional-signaling molecules, activated in response to wide …
is one such family of multifunctional-signaling molecules, activated in response to wide …