Does iso-mechanical power lead to iso-lung damage? An experimental study in a porcine model

F Vassalli, I Pasticci, F Romitti, E Duscio… - …, 2020 - pubs.asahq.org
Background Excessive tidal volume, respiratory rate, and positive end-expiratory pressure
(PEEP) are all potential causes of ventilator-induced lung injury, and all contribute to a …

Driving pressure: a marker of severity, a safety limit, or a goal for mechanical ventilation?

G Bugedo, J Retamal, A Bruhn - Critical care, 2017 - Springer
Current guidelines for lung-protective ventilation in patients with acute respiratory distress
syndrome (ARDS) suggest the use of low tidal volumes (Vt), set according to ideal body …

Airway and transpulmonary driving pressures and mechanical powers selected by INTELLiVENT-ASV in passive, mechanically ventilated ICU patients

JM Arnal, M Saoli, A Garnero - Heart & Lung, 2020 - Elsevier
Abstract Background Driving pressure (ΔP) and mechanical power (MP) are predictors of the
risk of ventilation-induced lung injuries (VILI) in mechanically ventilated patients …

Effect of Lowering Vt on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance

EC Goligher, ELV Costa, CJ Yarnell… - American journal of …, 2021 - atsjournals.org
Rationale: If the risk of ventilator-induced lung injury in acute respiratory distress syndrome
(ARDS) is causally determined by driving pressure rather than by Vt, then the effect of …

[HTML][HTML] Transpulmonary pressure: importance and limits

DL Grieco, L Chen, L Brochard - Annals of translational medicine, 2017 - ncbi.nlm.nih.gov
Transpulmonary pressure (PL) is computed as the difference between airway pressure and
pleural pressure and separates the pressure delivered to the lung from the one acting on …

Ventilatory variables and mechanical power in patients with acute respiratory distress syndrome

ELV Costa, AS Slutsky, LJ Brochard… - American journal of …, 2021 - atsjournals.org
Rationale: Mortality in acute respiratory distress syndrome (ARDS) has decreased after the
adoption of lung-protective strategies. Lower Vt, lower driving pressure (ΔP), lower …

Volutrauma and atelectrauma: which is worse?

L Gattinoni, M Quintel, JJ Marini - Critical Care, 2018 - Springer
The first recognized form of ventilator-induced lung injury (VILI) was named barotrauma, a
word that stresses the role of pressure as a causative agent [1]. Following the work of …