Mutations in the myostatin gene are associated with hypermuscularity, suggesting that
myostatin inhibits skeletal muscle growth. We postulated that increased tissue-specific …

Myostatin mutations in mice and cattle are associated with increased muscularity,
suggesting that myostatin is a negative regulator of skeletal muscle mass. To test the …

Constitutive myostatin gene knockout in mice causes excessive muscle growth during
development. To examine the effect of knocking out the myostatin gene after muscle has …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

Myostatin inhibits myogenesis. Therefore, we sought to determine if mice lacking the
myostatin gene [Mstn (-/-)] would lose less muscle mass than wild-type mice during 7 days of …

Inactivating mutations of the mammalian myostatin gene are associated with increased
muscle mass and decreased fat mass; conversely, myostatin transgenic mice that …

Myostatin is a master regulator of myogenesis and early postnatal skeletal muscle growth.
However, myostatin has been also involved in several forms of muscle wasting in adulthood …

Transgenic mice lacking a functional myostatin (MSTN) gene demonstrate greater skeletal
muscle mass resulting from muscle fiber hypertrophy and hyperplasia (McPherron, AC, AM …

Previous findings have provided strong evidence that myostatin functions as a negative
regulator of muscle mass during development and growth. In the present study, we test the …

OBJECTIVE—Obesity is associated with endocrine abnormalities that predict the
progression of insulin resistance to type 2 diabetes. Because skeletal muscle has been …