We cloned and characterized a 3.3-kb fragment containing the 5′-regulatory region of the
human myostatin gene. The promoter sequence contains putative muscle growth response …

Purpose There is mounting evidence that skeletal muscle produces and secretes
biologically active proteins or “myokines” that facilitate metabolic cross talk between organ …

Myostatin is a TGF-β family member that acts as a negative regulator of muscle growth. Mice
lacking the myostatin gene (Mstn) have a widespread increase in skeletal muscle mass …

Myostatin is a member of the TGF-β superfamily that is essential for proper regulation of
skeletal muscle growth. As do other TGF-β superfamily members, myostatin signals into the …

▪ Abstract Myostatin is a secreted protein that acts as a negative regulator of skeletal muscle
mass. During embryogenesis, myostatin is expressed by cells in the myotome and in …

Myostatin is a secreted growth and differentiating factor (GDF‐8) that belongs to the
transforming growth factor‐beta (TGF‐β) superfamily. Targeted disruption of the myostatin …

Objective Myostatin is a secreted growth factor expressed in skeletal muscle tissue, which
negatively regulates skeletal muscle mass. Recent animal studies suggest a role for …

Both acquired and inherited disorders of muscle are common; thus, greater understanding of
muscle growth and maintenance is important for future therapies. Myostatin down-regulates …

Mice and cattle with genetic deficiencies in myostatin exhibit dramatic increases in skeletal
muscle mass, suggesting that myostatin normally suppresses muscle growth. Whether this …

The discovery of myostatin and our introduction to the “Mighty Mouse” over a decade ago
spurred both basic and applied research and impacted popular culture as well. The …