Effects of macromolecular crowding on protein folding and aggregation studied by density functional theory: dynamics
AR Kinjo, S Takada - Physical Review E, 2002 - APS
Inside the living cell is inherently crowded with proteins and other macromolecules. Thus, it
is indispensable to take into account various interactions between the protein and other …
is indispensable to take into account various interactions between the protein and other …
Effects of macromolecular crowding on protein folding and aggregation studied by density functional theory: statics
AR Kinjo, S Takada - Physical Review E, 2002 - APS
Proteins are neither purified nor diluted inside the living cell. Thus it is indispensable to take
into account various interactions between the protein of interest and other macromolecules …
into account various interactions between the protein of interest and other macromolecules …
On protein folding in crowded conditions
The interior of a cell is a highly packed environment that can be occupied up to 40% by
different macromolecules. Such crowded media influence different biochemical processes …
different macromolecules. Such crowded media influence different biochemical processes …
Competition between protein folding and aggregation with molecular chaperones in crowded solutions: insight from mesoscopic simulations
AR Kinjo, S Takada - Biophysical journal, 2003 - cell.com
The living cell is inherently crowded with proteins and macromolecules. To avoid
aggregation of denatured proteins in the living cell, molecular chaperones play important …
aggregation of denatured proteins in the living cell, molecular chaperones play important …
Macromolecular crowding induces polypeptide compaction and decreases folding cooperativity
D Tsao, NV Dokholyan - Physical Chemistry Chemical Physics, 2010 - pubs.rsc.org
A cell's interior is comprised of macromolecules that can occupy up to 40% of its available
volume. Such crowded environments can influence the stability of proteins and their rates of …
volume. Such crowded environments can influence the stability of proteins and their rates of …
Protein folding/unfolding in the presence of interacting macromolecular crowders
A Irbäck, S Mohanty - The European Physical Journal Special Topics, 2017 - Springer
Recent years have seen an increasing number of biophysical studies of proteins being
conducted in cells and concentrated protein solutions. In these experiments, compared to …
conducted in cells and concentrated protein solutions. In these experiments, compared to …
Protein unfolding in crowded milieu: what crowding can do to a protein undergoing unfolding?
OV Stepanenko, OI Povarova… - Journal of …, 2016 - Taylor & Francis
The natural environment of a protein inside a cell is characterized by the almost complete
lack of unoccupied space, limited amount of free water, and the tightly packed crowd of …
lack of unoccupied space, limited amount of free water, and the tightly packed crowd of …
Dependence of protein folding stability and dynamics on the density and composition of macromolecular crowders
We investigate the effect of macromolecular crowding on protein folding, using purely
repulsive crowding particles and a self-organizing polymer model of protein folding. We find …
repulsive crowding particles and a self-organizing polymer model of protein folding. We find …
Simulation and modeling of crowding effects on the thermodynamic and kinetic properties of proteins with atomic details
Recent experimental studies of protein folding and binding under crowded solutions suggest
that crowding agents exert subtle influences on the thermodynamic and kinetic properties of …
that crowding agents exert subtle influences on the thermodynamic and kinetic properties of …
Studies of effects of macromolecular crowding and confinement on protein folding and protein stability
G Ping, JM Yuan, Z Sun, Y Wei - Journal of Molecular …, 2004 - Wiley Online Library
In cells, proteins execute specific tasks in crowded environments; these environments
influence their stability and dynamics. Similarly, for an enzyme molecule encapsulated in an …
influence their stability and dynamics. Similarly, for an enzyme molecule encapsulated in an …