Effects of macromolecular crowding on protein folding and aggregation studied by density functional theory: dynamics

AR Kinjo, S Takada - Physical Review E, 2002 - APS
Inside the living cell is inherently crowded with proteins and other macromolecules. Thus, it
is indispensable to take into account various interactions between the protein and other …

Effects of macromolecular crowding on protein folding and aggregation studied by density functional theory: statics

AR Kinjo, S Takada - Physical Review E, 2002 - APS
Proteins are neither purified nor diluted inside the living cell. Thus it is indispensable to take
into account various interactions between the protein of interest and other macromolecules …

On protein folding in crowded conditions

D Gomez, K Huber, S Klumpp - The Journal of Physical Chemistry …, 2019 - ACS Publications
The interior of a cell is a highly packed environment that can be occupied up to 40% by
different macromolecules. Such crowded media influence different biochemical processes …

Competition between protein folding and aggregation with molecular chaperones in crowded solutions: insight from mesoscopic simulations

AR Kinjo, S Takada - Biophysical journal, 2003 - cell.com
The living cell is inherently crowded with proteins and macromolecules. To avoid
aggregation of denatured proteins in the living cell, molecular chaperones play important …

Macromolecular crowding induces polypeptide compaction and decreases folding cooperativity

D Tsao, NV Dokholyan - Physical Chemistry Chemical Physics, 2010 - pubs.rsc.org
A cell's interior is comprised of macromolecules that can occupy up to 40% of its available
volume. Such crowded environments can influence the stability of proteins and their rates of …

Protein folding/unfolding in the presence of interacting macromolecular crowders

A Irbäck, S Mohanty - The European Physical Journal Special Topics, 2017 - Springer
Recent years have seen an increasing number of biophysical studies of proteins being
conducted in cells and concentrated protein solutions. In these experiments, compared to …

Protein unfolding in crowded milieu: what crowding can do to a protein undergoing unfolding?

OV Stepanenko, OI Povarova… - Journal of …, 2016 - Taylor & Francis
The natural environment of a protein inside a cell is characterized by the almost complete
lack of unoccupied space, limited amount of free water, and the tightly packed crowd of …

Dependence of protein folding stability and dynamics on the density and composition of macromolecular crowders

J Mittal, RB Best - Biophysical journal, 2010 - cell.com
We investigate the effect of macromolecular crowding on protein folding, using purely
repulsive crowding particles and a self-organizing polymer model of protein folding. We find …

Simulation and modeling of crowding effects on the thermodynamic and kinetic properties of proteins with atomic details

HX Zhou, S Qin - Biophysical reviews, 2013 - Springer
Recent experimental studies of protein folding and binding under crowded solutions suggest
that crowding agents exert subtle influences on the thermodynamic and kinetic properties of …

Studies of effects of macromolecular crowding and confinement on protein folding and protein stability

G Ping, JM Yuan, Z Sun, Y Wei - Journal of Molecular …, 2004 - Wiley Online Library
In cells, proteins execute specific tasks in crowded environments; these environments
influence their stability and dynamics. Similarly, for an enzyme molecule encapsulated in an …