Immunity to influenza: impact of obesity

SA Rojas-Osornio, TR Cruz-Hernández… - Obesity Research & …, 2019 - Elsevier
Obesity is a health concern that is recognized as a critical factor for vulnerability to influenza
A/pdmH1N1 virus infection, with epidemiological and clinical impacts. In humans, obesity …

Influence of obesity on the response to influenza infection and vaccination

EA Karlsson, JJ Milner, WD Green, J Rebeles… - … and manifestations of …, 2019 - Elsevier
Following the 2009 influenza pandemic, obesity was first recognized as an independent risk
factor for increased severity from the influenza pandemic strain, pdmH1N1. Further …

Obesity is associated with impaired immune response to influenza vaccination in humans

PA Sheridan, HA Paich, J Handy, EA Karlsson… - International journal of …, 2012 - nature.com
Background: Obesity is an independent risk factor for morbidity and mortality from pandemic
influenza H1N1. Influenza is a significant public health threat, killing an estimated 250 000 …

Obesity dysregulates the immune response to influenza infection and vaccination through metabolic and inflammatory mechanisms

SR Shaikh, NJ MacIver, MA Beck - Annual review of nutrition, 2022 - annualreviews.org
The COVID-19 pandemic demonstrates that obesity alone, independent of comorbidities, is
a significant risk factor for severe outcomes from infection. This susceptibility mirrors a …

Impact of obesity on influenza A virus pathogenesis, immune response, and evolution

R Honce, S Schultz-Cherry - Frontiers in immunology, 2019 - frontiersin.org
With the rising prevalence of obesity has come an increasing awareness of its impact on
communicable disease. As a consequence of the 2009 H1N1 influenza A virus pandemic …

Obesity impairs the adaptive immune response to influenza virus

WD Green, MA Beck - Annals of the American Thoracic Society, 2017 - atsjournals.org
Influenza, a highly contagious respiratory tract infection, affects millions of adults and
children each year. Several high-risk populations include children, the elderly, the …

Prostaglandin E2-Mediated Impairment of Innate Immune Response to A(H1N1)pdm09 Infection in Diet-Induced Obese Mice Could Be Restored by Paracetamol

AJX Zhang, H Zhu, Y Chen, C Li, C Li… - The Journal of …, 2019 - academic.oup.com
Background Obesity is associated with increased severity of influenza infection. However,
the underlying mechanism is largely unknown. Methods We employed a mouse model with …

The impact of obesity on the immune response to infection

JJ Milner, MA Beck - Proceedings of the Nutrition Society, 2012 - cambridge.org
There is strong evidence indicating that excess adiposity negatively impacts immune
function and host defence in obese individuals. This is a review of research findings …

[PDF][PDF] The impact of obesity on immune response to infection and vaccine: an insight into plausible mechanisms

P Bandaru, H Rajkumar… - Endocrinol Metab Synd, 2013 - researchgate.net
Though we know much about development of obesity and its associated complications like
type II diabetes, cardiovascular diseases, hypertension and cancer, our knowledge is very …

Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine

HL Park, SH Shim, EY Lee, W Cho, S Park… - Human vaccines & …, 2014 - Taylor & Francis
The relationship between obesity and vaccine efficacy is a serious issue. Previous studies
have shown that vaccine efficacy is lower in the obese than in the non-obese. Here, we …