The adenosine A3 receptor was initially cloned from a rat testis cDNA library. 4
Subsequently, A3 receptors have been cloned from human, 5, 6 sheep, 7 mouse, 8 and …

SUMMARY A novel adenosine receptor, the A 3 receptor, has recently been cloned. We
have systematically investigated the hitherto largely unexplored structure-activity …

We have characterized the in vitro pharmacological profile of the new potent and selective
A2a adenosine receptor antagonist SCH 58261 [7-(2-phenylethyl)-5-amino-2-(2-furyl) …

There is now good reason to believe that blockade of the adenosine A 2A receptor could be
of value in the treatment of Parkinson's disease. Peter J. Richardson, Hiroshi Kase and Peter …

Developments in the field of adenosine receptor (AR) agonists of the past years are
presented and discussed. Four different AR subtypes, A1, A2A, A2B, and A3, have been …

Binding affinities of purine derivatives at A3 adenosine receptors in different species were
compared. Binding was carried out using the novel high affinity agonist ligand [125I] AB …

Agonists bind with higher affinity to G protein-coupled heptahelical receptors than to
uncoupled receptors. Recombinant A1 and A3 adenosine receptors couple well to Gi/o, but …

The identification and characterization of adenosine receptors and the development of
potent, receptor subtype-selective agonist and antagonists has been an active area of …

Polyclonal antisera were generated against two identical regions of rat and human A1
adenosine receptors using synthetic multiple-antigenic-peptides as immunogens. Western …

Endogenous adenosine in nervous tissue, a central link between energy metabolism and
neuronal activity, varies according to behavioral state and (patho) physiological conditions; it …