Challenges associated with tyrosine kinase inhibitor therapy for metastatic thyroid cancer

ME Cabanillas, MI Hu, JB Durand… - Journal of thyroid …, 2011 - Wiley Online Library
Tyrosine kinase inhibitors (TKIs) which target angiogenesis are promising treatments for
patients with metastatic medullary and differentiated thyroid cancers. Sorafenib, sunitinib …

[HTML][HTML] Targeted therapies for thyroid tumors

SI Sherman - Modern Pathology, 2011 - Elsevier
Systemic chemotherapies for advanced or metastatic thyroid carcinomas have been of only
limited effectiveness. For patients with differentiated or medullary carcinomas unresponsive …

Tyrosine kinase inhibitor treatments in patients with metastatic thyroid carcinomas: a retrospective study of the TUTHYREF network

MH Massicotte, M Brassard… - European journal of …, 2014 - academic.oup.com
Abstract Objective Tyrosine kinase inhibitors (TKIs) are used to treat patients with advanced
thyroid cancers. We retrospectively investigated the efficacy of TKIs administered outside of …

[HTML][HTML] Novel targeted therapies for metastatic thyroid cancer—a comprehensive review

M Al-Jundi, S Thakur, S Gubbi, J Klubo-Gwiezdzinska - Cancers, 2020 - mdpi.com
The knowledge on thyroid cancer biology has grown over the past decade. Thus, diagnostic
and therapeutic strategies to manage thyroid cancer are rapidly evolving. With new insights …

Comparative efficacy and safety of tyrosine kinase inhibitors for thyroid cancer: a systematic review and meta-analysis

T Oba, T Chino, A Soma, T Shimizu, M Ono, T Ito… - Endocrine …, 2020 - jstage.jst.go.jp
The tyrosine kinase inhibitors (TKIs) sorafenib, lenvatinib, vandetanib, and cabozantinib are
currently used for thyroid cancer treatment; however, the differences in their clinical efficacy …

Management of tyrosine kinase inhibitors (TKI) side effects in differentiated and medullary thyroid cancer patients

C Resteghini, S Cavalieri, D Galbiati, R Granata… - Best practice & research …, 2017 - Elsevier
Four tyrosine kinase inhibitors (TKIs) have been recently licensed in thyroid cancer (TC),
sorafenib and lenvatinib for differentiated TC, vandetanib and cabozantinib for medullary …

Molecular targets of tyrosine kinase inhibitors in thyroid cancer

P Fallahi, SM Ferrari, MR Galdiero, G Varricchi… - Seminars in cancer …, 2022 - Elsevier
Thyroid cancer (TC) is the eighth most frequently diagnosed cancer worldwide with a rising
incidence in the past 20 years. Surgery is the primary strategy of therapy for patients with …

Targeted therapies in thyroid cancer: an extensive review of the literature

A Bikas, S Vachhani, K Jensen, V Vasko… - Expert Review of …, 2016 - Taylor & Francis
Introduction: Patients with progressive, metastatic, RAI-refractory differentiated thyroid
cancer (DTC), as well as patients with advanced medullary (MTC) and anaplastic thyroid …

New directions in the systemic treatment of metastatic thyroid cancer

A Forastiere, S Marur - Oncology, 2009 - search.proquest.com
Medical oncologists have traditionally had little to offer patients with metastatic radioactive
iodine-resistant thyroid cancer. The 3-year survival rate of patients with differentiated thyroid …

Therapy of endocrine disease: response and toxicity of small-molecule tyrosine kinase inhibitors in patients with thyroid carcinoma: a systematic review and meta …

EN Klein Hesselink, D Steenvoorden… - European Journal of …, 2015 - academic.oup.com
Context Many tyrosine kinase inhibitors (TKIs) have been studied in patients with thyroid
carcinoma (TC). However, the effect and toxicity of various TKIs in differentiated TC (DTC) …