Background Compared with other statins, rosuvastatin has a relatively long half-life, which
may allow for the administration of this medication on an alternate day basis. Objective To …

Background: Although most patients with hypercholesterolemia require life-long therapy with
statins, these drugs are underused due to high costs. Every-other-day therapy could be one …

Background Nondaily statin dosing is an alternative for patients unable to tolerate daily
dosing. The higher potency and longer half-life of rosuvastatin lends itself to this regimen …

Objective The primary objective of this trial was to compare the efficacy of rosuvastatin with
that of pravastatin and simvastatin for lowering low-density lipoprotein cholesterol (LDL-C) …

BACKGROUND: Alternative dosing is often used clinically to address common barriers with
statin therapy, such as intolerance and cost. Previous findings have demonstrated significant …

Rosuvastatin is a new, synthetic, orally active statin, with marked low-density lipoprotein
(LDL) cholesterol-lowering activity. We conducted 2 dose-ranging studies. In the first study …

A total of 5 randomized, double-blind trials in patients with hypercholesterolemia were
prospectively designed to allow pooling of plasma lipid data after 12 weeks of treatment. The …

The purpose of this study was to determine the efficacy of rosuvastatin dosed once a week in
patients with a previous statin adverse event. Rosuvastatin once a week was tolerated by 37 …

The primary objective of this 6-week, parallel-group, open-label, randomized, multicenter
trial was to compare rosuvastatin with atorvastatin, pravastatin, and simvastatin across dose …

Background Despite the demonstrated benefits of low-density lipoprotein cholesterol (LDL-
C) reduction in reducing the risk of coronary heart disease, many patients receiving lipid …