In silico screening and in vitro activity measurement of javamide analogues as potential p38 MAPK inhibitors

JB Park - International Journal of Molecular Sciences, 2017 - mdpi.com
p38 Mitogen-activated protein kinase (p38 MAPK) is a protein kinase critically involved in
the progress of inflammation/stress-associated diseases. Our data suggested that javamide …

Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation

A Astolfi, M Kudolo, J Brea, G Manni, G Manfroni… - European Journal of …, 2019 - Elsevier
This work describes the rational discovery of novel chemotypes of p38α MAPK inhibitors
using a funnel approach consisting of several computer-aided drug discovery methods and …

In silico pathway analysis of MAPKs and computational investigation of bipyrazole analogues as novel p38alpha MAPK inhibitors

D Nedunuri, Y Adimulam… - International Journal of …, 2016 - inderscienceonline.com
Mitogen-Activated Protein Kinase (MAPK) belongs to one of the largest super-families of
proteins. The activity of most MAPKs is stimulated by a large variety of signals, including …

3D-QSAR and molecular docking analysis of biphenyl amide derivatives as p38α mitogen-activated protein kinase inhibitors

PS Ambure, RP Gangwal, AT Sangamwar - Molecular diversity, 2012 - Springer
The p38 α mitogen-activated protein (MAP) kinase plays a vital role in treating many
inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's …

Docking, synthesis and pharmacological activity of novel urea-derivatives designed as p38 MAPK inhibitors

R de Oliveira Lopes, NC Romeiro, CKF de Lima… - European journal of …, 2012 - Elsevier
p38 mitogen-activated protein kinase (p38 MAPK) is an important signal transducing
enzyme involved in many cellular regulations, including signaling pathways, pain and …

Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors

B Wu, HL Wang, L Pettus, RP Wurz… - Journal of medicinal …, 2010 - ACS Publications
The p38 mitogen-activated protein kinase (MAPK) plays an important role in the production
of proinflammatory cytokines, making it an attractive target for the treatment of various …

Design, synthesis, biological evaluation, and in silico studies of quinoxaline derivatives as potent p38α MAPK inhibitors

Anjali, P Kamboj, O Alam, H Patel, I Ahmad… - Archiv der …, 2024 - Wiley Online Library
A new series of quinoxaline derivatives possessing the hydrazone moiety were designed,
synthesized, and screened for in‐vitro anti‐inflammatory activity by the bovine serum …

Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor

M Terajima, T Inoue, K Magari, H Yamazaki… - European Journal of …, 2013 - Elsevier
Given the key role p38 mitogen-activated protein kinase (MAPK) plays in inflammatory
responses through the production of cytokines and inflammatory mediators, its inhibition is …

Ligand-based 3D pharmacophore design, virtual screening and molecular docking for novel p38 MAPK inhibitors

L He, R Dai, XR Zhang, SY Gao, YY He… - Medicinal Chemistry …, 2015 - Springer
The p38 mitogen-activated protein kinase (MAPK) identified in human monocytes represents
a potentially attractive therapeutic target for a class of cytokine suppressive anti …

3D-QSAR and molecular docking studies on fused pyrazoles as p38α mitogen-activated protein kinase inhibitors

P Lan, ZJ Huang, JR Sun, WM Chen - International journal of molecular …, 2010 - mdpi.com
The p38α mitogen-activated protein kinase (MAPK) has become an attractive target for the
treatment of many diseases such as rheumatoid arthritis, inflammatory bowel disease and …