[HTML][HTML] A new platform for autoimmune diseases. Inducing tolerance with liposomes encapsulating autoantigens
L Almenara-Fuentes, S Rodriguez-Fernandez… - … , Biology and Medicine, 2023 - Elsevier
Autoimmune diseases (AIDs) are caused by the loss of self-tolerance and destruction of
tissues by the host's immune system. Several antigen-specific immunotherapies, focused on …
tissues by the host's immune system. Several antigen-specific immunotherapies, focused on …
Liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis
I Pujol-Autonell, MJ Mansilla… - …, 2017 - Taylor & Francis
Aim: Based on the ability of apoptosis to induce immunological tolerance, liposomes were
generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our …
generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our …
[HTML][HTML] Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes
I Pujol-Autonell, A Serracant-Prat, M Cano-Sarabia… - PloS one, 2015 - journals.plos.org
Introduction The development of new therapies to induce self-tolerance has been an
important medical health challenge in type 1 diabetes. An ideal immunotherapy should …
important medical health challenge in type 1 diabetes. An ideal immunotherapy should …
Preclinical evaluation of antigen-specific nanotherapy based on phosphatidylserine-liposomes for type 1 diabetes
A Villalba, S Rodriguez-Fernandez… - Artificial Cells …, 2020 - Taylor & Francis
Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of
insulin-producing cells. Due to the ability of apoptotic cells clearance to induce tolerance, we …
insulin-producing cells. Due to the ability of apoptotic cells clearance to induce tolerance, we …
[HTML][HTML] Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes
I Garcia-Loza, D Perna-Barrull, E Aguilera… - Journal of …, 2024 - Elsevier
Abstract Type 1 diabetes (T1D) results from a breakdown in immunological tolerance, with
pivotal involvement of antigen-presenting cells. In this context, antigen-specific …
pivotal involvement of antigen-presenting cells. In this context, antigen-specific …
Time-controlled phagocytosis of asymmetric liposomes: Application to phosphatidylserine immunoliposomes binding HIV-1 virus-like particles
RA Petazzi, A Gramatica, A Herrmann… - … , Biology and Medicine, 2015 - Elsevier
Macrophage immune functions such as antibody-mediated phagocytosis are strongly
impaired in individuals affected by HIV-1. Nevertheless, infected macrophages are still able …
impaired in individuals affected by HIV-1. Nevertheless, infected macrophages are still able …
[HTML][HTML] Designing antigens for the prevention and treatment of autoimmune diseases
DC Wraith - Current opinion in chemical engineering, 2018 - Elsevier
Highlights•Dendritic cells can present antigen in either an immunogenic or tolerogenic
manner.•Liposomes and nanoparticles can deliver antigens to antigen presenting …
manner.•Liposomes and nanoparticles can deliver antigens to antigen presenting …
Multivalent Scaffolds to Promote B cell Tolerance
Autoimmune diseases are characterized by aberrant immune responses toward self-
antigens. Current treatments lack specificity, promoting adverse effects by broadly …
antigens. Current treatments lack specificity, promoting adverse effects by broadly …
Suppression of autoimmune rheumatoid arthritis with hybrid nanoparticles that induce B and T cell tolerance to self-antigen
Autoimmune diseases affect over 4% of the world's population. Treatments are generally
palliative or use broad spectrum immunosuppressants to reduce symptoms and disease …
palliative or use broad spectrum immunosuppressants to reduce symptoms and disease …
An insight into the role of liposomal therapeutics in the reversion of multiple sclerosis
ABSTRACT Introduction Multiple Sclerosis (MS), as an autoimmune disease, has
complicated immunopathology, which makes its management relevant to various factors …
complicated immunopathology, which makes its management relevant to various factors …