Cholinergic dysfunction has been associated with cognitive abnormalities in a variety of
neurodegenerative and neuropsychiatric diseases. Here we tested how information …

Extensive physiological research has demonstrated a number of common effects of
acetylcholine within cortical structures, including the hippocampus, piriform cortex, and …

The activity of the septo-hippocampul and nucleus basalis-cortical cholinergic pathways was
investigated by measuring changes in the extracellular acetylcholine levels in the …

Basal forebrain cholinergic neurons, which innervate the hippocampus and cortex, have
been implicated in many forms of cognitive function. Immunolesion-based methods in …

Acetylcholine has long been implicated in memory, including hippocampal-dependent
memory, but the specific role for this neurotransmitter is difficult to identify in human …

Acetylcholine regulates the cerebral cortex to sharpen sensory perception and enhance
attentional focus. The cellular and circuit mechanisms of this cholinergic modulation are …

Acetylcholine plays an important role in cognitive function, as shown by pharmacological
manipulations that impact working memory, attention, episodic memory and spatial memory …

In vivo microdialysis was employed to monitor acetylcholine release in the hippocampus
and frontal cortex of freely behaving rats. Four stimuli were presented on separate occasions …

Previous efforts aimed at attributing discrete behavioral functions to cortical cholinergic
afferents have not resulted in a generally accepted hypothesis about the behavioral …

Recent studies have highlighted a variety of cognitive effects caused by cholinolytic drug
injections into different cortical structures. These findings were largely interpreted as …