Local delivery of doxorubicin prodrug via lipid nanocapsule–based hydrogel for the treatment of glioblastoma

M Wang, R Bergès, A Malfanti, V Préat… - Drug delivery and …, 2023 - Springer
Glioblastoma (GBM) recurrences appear in most cases around the resection cavity borders
and arise from residual GBM cells that cannot be removed by surgery. Here, we propose a …

Injectable nanomedicine hydrogel for local chemotherapy of glioblastoma after surgical resection

C Bastiancich, J Bianco, K Vanvarenberg… - Journal of controlled …, 2017 - Elsevier
Glioblastoma (GBM) treatment includes, when possible, surgical resection of the tumor
followed by radiotherapy and oral chemotherapy with temozolomide, however recurrences …

Glioblastoma-targeted, local and sustained drug delivery system based on an unconventional lipid nanocapsule hydrogel

C Gazaille, E Bozzato, N Madadian-Bozorg… - Biomaterials …, 2023 - Elsevier
The objective of this work was to develop an implantable therapeutic hydrogel that will
ensure continuity in treatment between surgery and radiochemotherapy for patients with …

Evaluation of lauroyl-gemcitabine-loaded hydrogel efficacy in glioblastoma rat models

C Bastiancich, L Lemaire, J Bianco, F Franconi… - …, 2018 - Taylor & Francis
Aim: Anticancer drug-loaded hydrogels are a promising strategy for the local treatment of
incurable brain tumors such as glioblastoma (GBM). Recently, we demonstrated the efficacy …

Drug combination using an injectable nanomedicine hydrogel for glioblastoma treatment

C Bastiancich, E Bozzato, U Luyten, F Danhier… - International Journal of …, 2019 - Elsevier
Lauroyl-gemcitabine lipid nanocapsules (GemC 12-LNC) hydrogel, administered
intratumorally or perisurgically in the tumor resection cavity, increases animal survival in …

Dual-drug loaded nanomedicine hydrogel as a therapeutic platform to target both residual glioblastoma and glioma stem cells

E Bozzato, N Tsakiris, A Paquot, GG Muccioli… - International journal of …, 2022 - Elsevier
Glioblastoma (GBM) recurrences are inevitable, and mainly originate from residual tumor
cells and the presence of glioma stem cells (GSC) around the resection cavity borders. We …

Lauroyl-gemcitabine-loaded lipid nanocapsule hydrogel for the treatment of glioblastoma

C Bastiancich, K Vanvarenberg, B Ucakar… - Journal of Controlled …, 2016 - Elsevier
The local delivery of chemotherapeutic agents is a very promising strategy for the treatment
of glioblastoma (GBM). Gemcitabine is a chemotherapeutic agent that has a different …

Doxorubicin-loaded liposome-like particles embedded in chitosan/hyaluronic acid-based hydrogels as a controlled drug release model for local treatment of …

S Adiguzel, M Karamese, S Kugu, EA Kacar… - International Journal of …, 2024 - Elsevier
Glioblastoma (GBM) resection and medication treatment are limited, and local drug
therapies are required. This study aims to create a hybrid system comprising liposome-like …

Anticancer drug-loaded hydrogels as drug delivery systems for the local treatment of glioblastoma

C Bastiancich, P Danhier, V Préat, F Danhier - Journal of Controlled …, 2016 - Elsevier
Among central nervous system tumors, Glioblastoma (GBM) is the most common, aggressive
and neurological destructive primary brain tumor in adults. Standard care therapy for GBM …

Liposome-based glioma targeted drug delivery enabled by stable peptide ligands

X Wei, J Gao, C Zhan, C Xie, Z Chai, D Ran… - Journal of Controlled …, 2015 - Elsevier
The treatment of glioma is one of the most challenging tasks in clinic. As an intracranial
tumor, glioma exhibits many distinctive characteristics from other tumors. In particular …