Despite intensive study, the role of CCR5 in cancer remains elusive. We showed that CCR5
expression by both CD4+ and CD8+ T cells is necessary to boost anti-tumor responses by …

Immune responses against cancer rely upon leukocyte trafficking patterns that are
coordinated by chemokines. CCR5, the receptor for chemotactic chemokines MIP1alpha …

Extensive evidence implicates CCR5 and its ligands in the biology of tumors, although there
is considerable controversy regarding the role of this chemokine receptor in cancer …

Experiments of nature have revealed the peculiar importance of the G-protein–coupled
receptor, CC chemokine receptor type 5 (CCR5), in human disease since ancient times. The …

Cancer is currently one of the leading causes of death worldwide and is one of the most
challenging major public health problems. The main challenges faced by clinicians in the …

Solid tumors are embedded in a stromal microenvironment consisting of immune cells, such
as macrophages and lymphocytes, as well as nonimmune cells, such as endothelial cells …

Since 2001, the association of CCR7 expression by tumor cells with LN metastasis (and
associated poor clinical outcome) has been validated in a large number of solid tumors as …

Introduction Chemokines and their cognate receptors play a major role in modulating
inflammatory responses. Depending on their ligand binding, chemokine receptors can …

The chemokine receptor CCR4 is preferentially expressed on certain immune cells and
some hematological tumor cells, which play pivotal roles in suppression of host immune …

Tumor expression of certain chemokine receptors is associated with resistance to apoptosis,
migration, invasiveness and metastasis. Because CCR9 chemokine receptor expression is …