The multistep process of carcinogenesis, which can take many years, provides many
opportunities for intervention to inhibit disease progression. Effective chemoprevention …

Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …

Tumorigenesis is a complex process, and understanding the mechanisms behind
tumorigenesis is key to identifying effective targeted therapies. Prostaglandins are signaling …

Cyclooxygenase-2 (COX-2) is being intensively evaluated as a pharmacologic target for
both the prevention and treatment of cancer. Aberrant COX-2 expression was initially …

A major goal in the area of cancer prevention and treatment is to make rational use of
defined molecular targets in order to block carcinogenesis. Studies conducted in …

Cyclooxygenase (COX) inhibitors are being developed as potential agents for the
prevention and treatment of cancer after a century of widespread use for inflammation, fever …

Epidemiological and experimental studies have demonstrated the effect of non-steroidal anti-
inflammatory drugs (NSAIDs) in the prevention of human cancers. NSAIDs block …

In addition to the well-established pathophysiological role that COX-2 plays in inflammation,
recent evidence implies that this isoform may also be involved in multiple biologic events …

The cyclo-oxygenase (COX) metabolic pathway and prostaglandin (PG) production appear
to play a causal role in the promotion and progression of human cancers. COX-1 and COX-2 …

The revelation that aspirin and aspirin-like compounds have notableantineo plastic
properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and …