Objective: Oxidative stress has increasingly been implicated in the development and
progression of many vascular diseases. Previous work from our laboratory indicated that …

Recently, we showed that genetic factors determine flow-dependent vascular remodeling.
Among five inbred mouse strains, the SJL strain developed the largest intima in response to …

Recent work has made it clear that oxidant systems interact. To investigate potential cross
talk between NADPH oxidase (Nox) 1 upregulation in vascular smooth muscle and …

Nitric oxide (NO) and reactive oxygen species (ROS) have fundamentally important roles in
the regulation of vascular tone and remodeling. Although arterial disease and endothelial …

Peroxynitrite, a marker of oxidative stress, is elevated in conditions associated with vascular
endothelial cell dysfunction, such as atherosclerosis, preeclampsia, and diabetes. However …

Salt-sensitive hypertension is associated with impaired NO/cGMP signaling. We
hypothesized that increased superoxide production by NADPH oxidase and altered …

Objective: Endothelial NADPH oxidase is a major source of superoxide in blood vessels and
is implicated in the oxidative stress accompanying vascular diseases, including …

Arterial hypertension is associated with increased levels of reactive oxygen species, which
may scavenge endothelium-derived NO and thereby diminish its vasorelaxant effects …

Objective: Enhanced oxidative stress is involved in mediating the endothelial dysfunction
associated with hypertension. The aim of this study was to investigate the relative …

The role of mitochondrial manganese-superoxide dismutase (Mn-SOD) in the maintenance
of vascular function has not yet been studied. Thus we examined flow-and agonist-induced …