The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration
HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a quantitative trait in human plasma. Lp (a) consists of a
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …
Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations.
E Boerwinkle, CC Leffert, J Lin… - The Journal of …, 1992 - Am Soc Clin Investig
Plasma lipoprotein (a)[Lp (a)], a low density lipoprotein particle with an attached
apolipoprotein (a)[apo (a)], varies widely in concentration between individuals. These …
apolipoprotein (a)[apo (a)], varies widely in concentration between individuals. These …
Sequence polymorphisms in the apolipoprotein (a) gene. Evidence for dissociation between apolipoprotein (a) size and plasma lipoprotein (a) levels.
JC Cohen, G Chiesa, HH Hobbs - The Journal of clinical …, 1993 - Am Soc Clin Investig
Apolipoprotein (a)[apo (a)], an apolipoprotein unique to lipoprotein (a)[Lp (a)], is highly
polymorphic in size. Previous studies have indicated that the size of the apo (a) gene tends …
polymorphic in size. Previous studies have indicated that the size of the apo (a) gene tends …
Sequence polymorphisms in the apo (a) gene associated with specific levels of Lp (a) in plasma
V Mooser, FP Mancini, S Bopp… - Human molecular …, 1995 - academic.oup.com
Most of the Interindividual variations in plasma levels of lipoprotein (a)[Lp (a)] can be
attributed to sequence differences linked to the apolipoprotein (a)[apo (a)] locus. Plasma …
attributed to sequence differences linked to the apolipoprotein (a)[apo (a)] locus. Plasma …
Expressed hypervariable polymorphism of apolipoprotein (a).
MI Kamboh, RE Ferrell, BA Kottke - American journal of human …, 1991 - ncbi.nlm.nih.gov
Elevated plasma lipoprotein (a)(LP (a] levels are an independent predictor of the
development of premature atherosclerosis in humans. The LP (a) particle consists of two …
development of premature atherosclerosis in humans. The LP (a) particle consists of two …
Genetic linkage between lipoprotein (a) phenotype and a DNA polymorphism in the plasminogen gene
Coronary heart disease risk correlates directly with plasma concentrations of lipoprotein
(a)(Lp (a)), a lowdensity lipoprotein-like particle distinguished by the presence of the …
(a)(Lp (a)), a lowdensity lipoprotein-like particle distinguished by the presence of the …
The apolipoprotein (a) gene resides on human chromosome 6q26–27, in close proximity to the homologous gene for plasminogen
SL Frank, I Klisak, RS Sparkes, T Mohandas… - Human genetics, 1988 - Springer
Summary Apolipoprotein (a)[apo (a)], the glycoprotein associated with the lipoprotein (a)[Lp
(a)] subfraction of plasma lipoproteins, has been shown to exhibit heritable molecular weight …
(a)] subfraction of plasma lipoproteins, has been shown to exhibit heritable molecular weight …
Plasma lipoprotein (a) levels and expression of the apolipoprotein (a) gene are dependent on the nucleotide polymorphisms in its 5'-flanking region.
K Suzuki, M Kuriyama, T Saito… - The Journal of clinical …, 1997 - Am Soc Clin Investig
The apolipoprotein (a)(apo [a]) gene encodes a protein component of lipoprotein (a)[Lp (a)]
whose plasma levels vary widely among individuals. Hyper-Lp (a)-emia constitutes a risk …
whose plasma levels vary widely among individuals. Hyper-Lp (a)-emia constitutes a risk …
A pentanucleotide repeat polymorphism in the 5'control region of the apolipoprotein (a) gene is associated with lipoprotein (a) plasma concentrations in Caucasians.
M Trommsdorff, S Köchl, A Lingenhel… - The Journal of …, 1995 - Am Soc Clin Investig
The enormous interindividual variation in the plasma concentrations of the atherogenic
lipoprotein (a)[Lp (a)] is almost entirely controlled by the apo (a) locus on chromosome 6q26 …
lipoprotein (a)[Lp (a)] is almost entirely controlled by the apo (a) locus on chromosome 6q26 …
Genetics of the quantitative Lp (a) lipoprotein trait: III. Contribution of Lp (a) glycoprotein phenotypes to normal lipid variation
E Boerwinkle, HJ Menzel, HG Kraft, G Utermann - Human genetics, 1989 - Springer
Summary Apolipoprotein (a)[apo (a)] is a large serum glycoprotein with several genetically
determined isoforms differing in their apparent molecular weight. We determined the effects …
determined isoforms differing in their apparent molecular weight. We determined the effects …