Inflammation of the central nervous system (CNS)(neuroinflammation) is now recognized to
be a feature of all neurological disorders. In multiple sclerosis, there is prominent infiltration …

Following a cerebral ischemic event, substantial alterations in both cellular and molecular
activities occur due to ischemia-induced cerebral pathology. Mounting evidence indicates …

Background Systemic inflammation impairs outcome in stroke patients and experimental
animals via mechanisms which are poorly understood. Circulating inflammatory mediators …

Stroke is responsible for almost 6 million deaths and more than 10% of all mortalities each
year, and two-thirds of stroke survivors remain disabled. With treatments for ischemic stroke …

Review on the time-dependent recruitment of inflammatory cells and unanswered questions
regarding inflammatory cells in the pathophysiology of ischemic stroke. Inflammation plays …

Historically, the brain has been considered an immune-privileged organ separated from the
peripheral immune system by the blood–brain barrier. However, immune responses do …

The immune response to ischemic stroke is an area of study that is at the forefront of stroke
research and presents promising new avenues for treatment development. Upon cerebral …

After ischemic stroke, the integrity of the blood-brain barrier is compromised. Peripheral
immune cells, including neutrophils, T cells, B cells, dendritic cells, and macrophages …

Recent works in the area of stroke and brain ischemia has demonstrated the significance of
the inflammatory response accompanying necrotic brain injury. Acutely, this response …

Many advances have been achieved in terms of understanding the molecular and cellular
mechanisms of ischemic stroke. But thus far, clinically effective neuroprotectants remain …