In vitro assessment of cytochrome P450 2C19 potential of Naoxintong

H Chen, Y Zhang, X Wu, C Li… - … and Alternative Medicine, 2012 - Wiley Online Library
The effects of Buchang Naoxintong Capsules (BNCs) on S‐mephenytoin 4′‐hydroxylation
activities in human liver microsomes in vitro were assessed. Human liver microsome was …

Effect of naoxintong capsules on the activities of CYP450 and metabolism of metoprolol tartrate in rats evaluated by probe cocktail and pharmacokinetic methods

H Ouyang, J Shen, X Huang, W Ma… - Evidence‐Based …, 2019 - Wiley Online Library
Naoxintong capsule (NXT), a prescribed Chinese medicine, has been used clinically for
more than 20 years and is widely received by patients. We determined five probe drugs …

Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies

T Hu, X Zhou, L Wang, PMY Or, JHK Yeung… - Chemico-Biological …, 2015 - Elsevier
Objectives: This study aimed to investigate the effects of five tanshinones, the lipophilic
components from Danshen (Salvia miltiorrhiza), on CYP2C19 activity in pooled human liver …

Inhibitory and inductive effects of Phikud Navakot extract on human cytochrome P450

A Chiangsom, S Lawanprasert, S Oda… - Drug Metabolism and …, 2016 - Elsevier
Abstract Effects of the hydroethanolic extract of Phikud Navakot (PN), a Thai traditional
remedy, on human cytochrome P450s (CYPs) were investigated in vitro. Selective …

Inhibition Effect of Okanin Toward Human Cytochrome P450 3A4 and 2D6 with Multi-spectroscopic Studies and Molecular Docking

S Wang, M Wang, J Cui, D Lian, L Li - Journal of Fluorescence, 2024 - Springer
Okanin, a major flavonoid of a popular herb tea, Coreopsis tinctoria Nutt., showed strong
inhibition on CYP3A4 and CYP2D6. The strong interaction between okanin and CYPs were …

Inhibition of rat CYP1A2 and CYP2C11 by honokiol, a component of traditional Chinese medicine

J Li, M Li, B Sun, C Liu, J Ren, W Zhi, P Zhang… - European Journal of …, 2019 - Springer
Abstract Background and Objectives Honokiol, a major constituent isolated from Magnolia
officinalis, is regarded as a phytochemical marker and bioactive substance present in many …

Inhibitory effects of seven components of danshen extract on catalytic activity of cytochrome P450 enzyme in human liver microsomes

F Qiu, R Zhang, J Sun, A Jiye, H Hao, Y Peng… - Drug Metabolism and …, 2008 - ASPET
The potential for herb-drug interactions has recently received greater attention worldwide,
considering the fact that the use of herbal products becomes more and more widespread …

In vitro evaluation of the inhibition potential of echinacoside on human cytochrome P450 isozymes

Y Wu, A Qiao, S Lin, L Chen - BMC Complementary Medicine and …, 2022 - Springer
Background Echinacoside (ECH) possesses a wide range of biological activity. This present
study analyzes the effect of ECH on cytochrome P450 isozymes (CYPs) activities of human …

HPLC‐MS/MS Analysis of Aconiti Lateralis Radix Praeparata and Its Combination with Red Ginseng Effect on Rat CYP450 Activities Using the Cocktail Approach

W Ma, W Wang, X Huang, G Yao, Q Jia… - Evidence‐Based …, 2020 - Wiley Online Library
Red ginseng is often combined with Aconiti Lateralis Radix Praeparata to reduce alkaloids‐
related toxicity of the latter. Such herb‐pairing also results in better therapeutic effect in heart …

Risk assessment of the inhibition of hydroxygenkwanin on human and rat cytochrome P450 by cocktail method

J Gao, Y Zhang, X Lei, Y Xu, Z Sun, X Wang - Toxicology in Vitro, 2022 - Elsevier
Hydroxygenkwanin (HGK), a natural flavonoid extracted from the buds of Daphne genkwa
Sieb. et Zucc.(Thymelaeaceae), possesses a wide range of pharmacological activities …