[HTML][HTML] Copper oxide nanoparticle toxicity profiling using untargeted metabolomics

MSP Boyles, C Ranninger, R Reischl, M Rurik… - Particle and fibre …, 2015 - Springer
Background The rapidly increasing number of engineered nanoparticles (NPs), and
products containing NPs, raises concerns for human exposure and safety. With this …

Predictive metabolomic signatures for safety assessment of metal oxide nanoparticles

L Cui, X Wang, B Sun, T Xia, S Hu - Acs Nano, 2019 - ACS Publications
The widespread use of metal oxide nanoparticles (MOx NPs) poses a risk of exposure that
may lead to adverse health effects on humans. Even though a number of toxicological …

Metabolomics profiling to investigate nanomaterial toxicity in vitro and in vivo

A Bannuscher, B Hellack, A Bahl, J Laloy… - …, 2020 - Taylor & Francis
Nanomaterials (NMs) can be produced in plenty of variants posing several challenges for
NM hazard and risk assessment. Metabolomic profiling of NM-treated cells and tissues …

Metabolomics techniques for nanotoxicity investigations

M Lv, W Huang, Z Chen, H Jiang, J Chen, Y Tian… - Bioanalysis, 2015 - Future Science
Nanomaterials are commonly defined as engineered structures with at least one dimension
of 100 nm or less. Investigations of their potential toxicological impact on biological systems …

Lipidomics reveals insights on the biological effects of copper oxide nanoparticles in a human colon carcinoma cell line

NGC Soria, DS Aga, GE Atilla-Gokcumen - Molecular Omics, 2019 - pubs.rsc.org
Engineered nanomaterials have unique properties compared to their bulk counterparts.
Copper oxide nanoparticles (CuO NPs) are one example of nanomaterials used in a wide …

[HTML][HTML] Integration of metabolomics and transcriptomics in nanotoxicity studies

TH Shin, HS Lee, HJ Park, MS Jin, MJ Paik… - BMB …, 2018 - ncbi.nlm.nih.gov
Biomedical research involving nanoparticles has produced useful products with medical
applications. However, the potential toxicity of nanoparticles in biofluids, cells, tissues, and …

Impact of copper oxide particle dissolution on lung epithelial cell toxicity: response characterization using global transcriptional analysis

A Boyadzhiev, ML Avramescu, D Wu, A Williams… - …, 2021 - Taylor & Francis
The in vitro and in vivo toxicity of copper oxide nanoparticles (CuO NPs) is attributed to both
particle and dissolved copper ion species. However, a clear understanding of (1) the specific …

Transcriptional profiling reveals gene expression changes associated with inflammation and cell proliferation following short‐term inhalation exposure to copper oxide …

PM Costa, I Gosens, A Williams, L Farcal… - Journal of applied …, 2018 - Wiley Online Library
Our recent studies revealed a dose‐dependent proinflammatory response to copper oxide
nanoparticles (CuO NPs) in rats following short‐term inhalation exposure for five …

Copper oxide nanoparticles: In vitro and in vivo toxicity, mechanisms of action and factors influencing their toxicology

H Sajjad, A Sajjad, RT Haya, MM Khan, M Zia - … and Physiology Part C …, 2023 - Elsevier
Abstract Copper oxide nanoparticles (CuO NPs) have received increasing interest due to
their distinctive properties, including small particle size, high surface area, and reactivity …

Metabolomics techniques in nanotoxicology studies

LK Schnackenberg, J Sun, RD Beger - Nanotoxicity: Methods and …, 2012 - Springer
The rapid growth in the development of nanoparticles for uses in a variety of applications
including targeted drug delivery, cancer therapy, imaging, and as biological sensors has led …