Background Obesity and central obesity are multifactorial conditions with genetic and non-
genetic (lifestyle and environmental) contributions. There is incomplete understanding of …

The extent to which modifiable lifestyle factors offset the determined genetic risk of obesity
and obesity-related morbidities remains unknown. We explored how the interaction between …

Objective To investigate whether the association between a genetic profile risk score for
obesity (GPRS-obesity)(based on 93 SNPs) and body mass index (BMI) was modified by …

Aims/hypothesis Genetic pleiotropy may contribute to the clustering of obesity and metabolic
conditions. We assessed whether genetic variants that are robustly associated with BMI and …

Background Obesity is a global health problem mainly attributed to lifestyle changes such as
diet, low physical activity or socioeconomics factors. However, several evidences …

Numerous obesity loci have been identified using genome-wide association studies. A UK
study indicated that physical activity may attenuate the cumulative effect of 12 of these loci …

Background Obesity has tripled worldwide since 1975 as environments are becoming more
obesogenic. Our study investigates how changes in population weight and obesity over time …

Previous genome-wide association studies (GWAS) have identified hundreds of genetic loci
to be associated with body mass index (BMI) and risk of obesity. Genetic effects can differ …

Background: Obesity is rapidly becoming a global epidemic. Unlike many complex human
diseases, obesity is defined not just by a single trait or phenotype, but jointly by measures of …

Background: Data from meta-analyses of genome-wide association studies provided
evidence for an association of polymorphisms with body mass index (BMI), and gene …