An animal model of radiation-induced lung disease was established using male Wistar rats
given sublethal bilateral thoracic irradiation (15 Gy). The rats were studied for up to 20 …

Purpose: To characterize structural and functional injuries following a single dose of whole-
thorax irradiation that might be survivable after a nuclear attack/accident. Methods: Rats …

The development of lung fibrosis after single-dose thoracic irradiation was studied
histologically in C57L/J male mice. Lung function was monitored using uptake of carbon …

Mice were exposed to 2000 R of x-rays to the whole chest or to the right hemithorax. At
various periods, from 0 to 15 months after exposure, the changes in the ultrastructure of the …

Strain differences in the radiation response of mouse lung during the early phase (before 28
weeks postirradiation) were investigated histologically. The nine strains tested were divided …

Lung injury after localized irradiation of the thorax was quantified and compared in CBA and
C57Bl mice. Using lethality and breathing rate as end points, two phases of damage …

Strain differences in the intermediate and late phases of the radiation response of mouse
lung were investigated histologically. The proportion of lung impairment in mice at 28 and 52 …

The purpose of this study is to define differences in radiation sensitivity among rat strains
using breathing frequency and lung perfusion as end points of radiation-induced lung injury …

Using a large animal model of radiation lung injury-the sheep exposed to bilateral thoracic
irradiation-we have recently shown the development of sustained pulmonary hypertension …

The purpose of this study is to develop an experimental model to measure localized
radiation-induced lung injury using multiple end-points including breathing frequency, high …