Abstract Background The highly conserved Grainyhead‐like (Grhl) family of transcription
factors play critical roles in the development of the neural tube and craniofacial skeleton. In …

The highly-conserved Grainyhead-like (Grhl) transcription factors are critical regulators of
embryogenesis that regulate cellular survival, proliferation, migration and epithelial integrity …

Background Increased apposition of the frontal and parietal bones of the skull during
embryogenesis may be a risk factor for the subsequent development of premature skull …

Craniofacial development in vertebrates involves the coordinated growth, migration, and
fusion of several facial prominences during embryogenesis, processes governed by strict …

The transcription factor grainyhead-like 2 (GRHL2) is expressed in non-neural ectoderm
(NNE) and Grhl2 loss results in fully penetrant cranial neural tube defects (NTDs) in mice …

Orofacial clefts, including cleft lip and palate (CL/P) and neural tube defects (NTDs) are
among the most common congenital anomalies, but knowledge of the genetic basis of these …

The Drosophila grainyhead (grh) and vertebrate Grainyhead-like (Grhl) transcription factors
are among the most critical genes for epithelial development, maintenance and …

Grainyhead‐like genes are part of a highly conserved gene family that play a number of
roles in ectoderm development and maintenance in mammals. Here we identify a novel …

Cleft lip and palate are common birth defects resulting from failure of the facial processes to
fuse during development. The mammalian grainyhead-like (Grhl1-3) genes play key roles in …

Abstract Background The transcription factor Grainyhead‐like 3 (GRHL3) has multiple roles
in a variety of tissues during development including epithelial patterning and actin …