The activities of progesterone receptor isoform A and B are differentially modulated by their ligands in a gene‐selective manner

JCL Leo, VCL Lin - International Journal of Cancer, 2008 - Wiley Online Library
It is known that progesterone receptor (PR) isoform A (PR‐A) and isoform B (PR‐B) may
mediate different effects of progesterone. The objective of this study was to determine if the …

Characterization of progesterone receptor A and B expression in human breast cancer

JD Graham, C Yeates, RL Balleine, SS Harvey… - Cancer research, 1995 - AACR
The human progesterone receptor (PR) is a ligand-activated nuclear transcription factor that
mediates progesterone action in target tissues. Two PR proteins, PR-A (M r 81,000–83,000) …

Expression of progesterone receptor isoforms A and B is differentially regulated by estrogen in different breast cancer cell lines

A Vienonen, H Syvälä, S Miettinen, P Tuohimaa… - The Journal of steroid …, 2002 - Elsevier
Progesterone action in target tissues is mediated through two progesterone receptor (PR)
isoforms, PR-A and PR-B, which display different regulatory functions in target cells. Relative …

[HTML][HTML] Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells

JK Richer, BM Jacobsen, NG Manning, MG Abel… - Journal of Biological …, 2002 - ASBMB
The PR-A and PR-B isoforms of progesterone receptors (PR) have different physiological
functions, and their ratio varies widely in breast cancers. To determine whether the two PR …

[HTML][HTML] New human breast cancer cells to study progesterone receptor isoform ratio effects and ligand-independent gene regulation

BM Jacobsen, JK Richer, SA Schittone… - Journal of Biological …, 2002 - ASBMB
All known progesterone target cells coexpress two functionally different progesterone
receptor (PR) isoforms: 120-kDa B-receptors (PR-B) and N-terminally truncated, 94-kDa A …

Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: PR isoform-specific gene regulation and tumor …

BM Jacobsen, SA Schittone, JK Richer… - Molecular …, 2005 - academic.oup.com
Progesterone receptors (PRs) are prognostic markers in breast cancers irrespective of the
patient's progestational status. However, there are two PR isoforms, PR-A and PR-B, that are …

Progesterone receptor A and B protein expression in human breast cancer

JD Graham, C Yeates, RL Balleine, SS Harvey… - The Journal of steroid …, 1996 - Elsevier
The human progesterone receptor (PR) is a ligand-activated nuclear transcription factor
which mediates progesterone action in target tissues. Two PR proteins, PR A (81–83 kDa) …

[HTML][HTML] Preferential Stimulation of Human Progesterone Receptor B Expression by Estrogen in T-47D Human Breast Cancer Cells (∗)

JD Graham, SD Roman, E McGowan… - Journal of Biological …, 1995 - ASBMB
Human progesterone receptor (PR) expression is controlled by two promoter regions giving
rise to transcripts encoding PR A and B proteins. It is unknown whether estrogen and …

Characterization of a truncated progesterone receptor protein in breast tumors

C Yeates, SMN Hunt, RL Balleine… - The Journal of Clinical …, 1998 - academic.oup.com
The progesterone receptor (PR) mediates the actions of progesterone in the normal and
malignant breast. PR is expressed as two proteins, PR B and PR A, which are expressed in …

Progesterone receptor variants found in breast cells repress transcription by wild-type receptors

JK Richer, CA Lange, AM Wierman, KM Brooks… - Breast cancer research …, 1998 - Springer
Progesterone, through its nuclear receptors (PR), regulates the development and growth of
breast cancers. PR also serve as markers of hormone dependence and prognosis in …