Intersectins (ITSNs) represent a family of multi-domain adaptor proteins that regulate
endocytosis and cell signaling. ITSN genes are highly conserved and present in all …

Intersectin (ITSN) is a multi-domain scaffold protein with a diverse array of functions
including regulation of endocytosis, vesicle transport, and activation of various signal …

Intersectins (ITSNs) are a family of multi-domain proteins involved in regulation of diverse
cellular pathways. These scaffold proteins are well known for regulating endocytosis but …

The endocytic pathway is involved in activation and inhibition of cellular signaling. Thus,
defining the regulatory mechanisms that link endocytosis and cellular signaling is of interest …

Adaptor/scaffold proteins serve as platforms for the assembly of multiprotein complexes and
regulate the efficiency and specificity of signalling cascades. Intersectins (ITSNs) are an …

Intersectins (ITSNs) are a family of highly conserved proteins with orthologs from nematodes
to mammals. In vertebrates, ITSNs are encoded by two genes (itsn1 and itsn2), which act as …

Abstract Intersectin 1 (ITSN1) is an evolutionarily conserved adaptor protein that functions in
clathrin-mediated endocytosis, cell signalling and cytoskeleton rearrangements. The ITSN1 …

While endocytosis attenuates signals from plasma membrane receptors, recent studies
suggest that endocytosis also serves as a platform for the compartmentalized activation of …

Background Scaffolding proteins of the intersectin (ITSN) family, ITSN1 and ITSN2, are
crucial for the initiation stage of clathrin-mediated endocytosis. These proteins are closely …

Glioblastomas, the most aggressive form of primary brain tumors with a tendency to invade
surrounding healthy brain tissues, remains an incurable disease. Intersectin (ITSN) is a …