In recent years, complement analysis of body fluids and biopsies, going far beyond C3 and
C4, has significantly enhanced our understanding of the disease process. Such expanded …

Complement not only plays a key role in host microbial defense but also modulates the
adaptive immune response through modification of T-and B-cell reactivity. Moreover, a …

Complement system aberrations have been identified as pathophysiological mechanisms in
a number of diseases and pathological conditions either directly or indirectly. Examples of …

Background The complement system is an essential component of our innate defense and
plays a vital role in the pathogenesis of many diseases. Assessment of complement …

Complement immunobiology, and with it complement analysis, has undergone a
renaissance in the past decade. Classically, complement analysis was limited number of …

The complement system plays an important role in varying types of disease, ranging from
inflammatory and autoimmune disorders to immune deficiency states. In addition, new …

Aberrations in the complement system have been shown to be direct or indirect
pathophysiological mechanisms in a number of diseases and pathological conditions such …

Complement analysis in the clinic is usually associated with the quantification of C3 and C4,
measurement of C1-inhibitor and screening for complement activity. These analyses have …

The renaissance of complement diagnostics and therapeutics has introduced precision
medicine into a widened field of complement-mediated diseases. In particular, complement …

Introduction The complement system is involved in numerous diseases, through diverse
mechanisms and degree of activation. With the emergence of complement targeting …