Unfolding and disentangling coronary vascular disease through genome-wide association studies
J Erdmann, SW van der Laan - European Heart Journal, 2021 - academic.oup.com
From the day we are born, our arteries deteriorate. As we age, molecular and cellular decay
combined with a never-ceasing attack by internal and external factors (think: circulating …
combined with a never-ceasing attack by internal and external factors (think: circulating …
Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort
Type 2 diabetes (T2D) and cardiovascular disease (CVD) represent significant disease
burdens for most societies and susceptibility to these diseases is strongly influenced by diet …
burdens for most societies and susceptibility to these diseases is strongly influenced by diet …
Coronary heart disease risk prediction in the era of genome-wide association studies: current status and what the future holds
SE Humphries, F Drenos, G Ken-Dror, PJ Talmud - Circulation, 2010 - Am Heart Assoc
For DNA-based tests that assess genetic predisposition to coronary heart disease (CHD) to
be of clinical value, they need to provide information over and above conventional risk …
be of clinical value, they need to provide information over and above conventional risk …
Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits
Background: Causality between plasma triglyceride (TG) levels and atherosclerotic
cardiovascular disease (ASCVD) risk remains controversial despite more than four decades …
cardiovascular disease (ASCVD) risk remains controversial despite more than four decades …
Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease
Background Circulating blood lipids cause coronary heart disease (CHD). However, the
precise way in which one or more lipoprotein lipid-related entities account for this …
precise way in which one or more lipoprotein lipid-related entities account for this …
Interactions between enhanced polygenic risk scores and lifestyle for cardiovascular disease, diabetes, and lipid levels
Background: Both lifestyle and genetic factors confer risk for cardiovascular diseases, type 2
diabetes, and dyslipidemia. However, the interactions between these 2 groups of risk factors …
diabetes, and dyslipidemia. However, the interactions between these 2 groups of risk factors …
Bivariate genome-wide association scan identifies 6 novel loci associated with lipid levels and coronary artery disease
KM Siewert, BF Voight - Circulation: Genomic and Precision …, 2018 - Am Heart Assoc
Background: Plasma lipid levels are heritable and genetically associated with risk of
coronary artery disease (CAD). However, genome-wide association studies (GWAS) …
coronary artery disease (CAD). However, genome-wide association studies (GWAS) …
[HTML][HTML] Neural network-based integration of polygenic and clinical information: development and validation of a prediction model for 10-year risk of major adverse …
J Steinfeldt, T Buergel, L Loock, P Kittner… - The Lancet Digital …, 2022 - thelancet.com
Background In primary cardiovascular disease prevention, early identification of high-risk
individuals is crucial. Genetic information allows for the stratification of genetic …
individuals is crucial. Genetic information allows for the stratification of genetic …
Translating genetic association of lipid levels for biological and clinical application
Purpose of review This review focuses on the foundational evidence from the last two
decades of lipid genetics research and describes the current status of data-driven …
decades of lipid genetics research and describes the current status of data-driven …
Use of polygenic risk scores and other molecular markers to enhance cardiovascular risk prediction: prospective cohort study and modelling analysis
L Sun, L Pennells, S Kaptoge, CP Nelson, G Abraham… - bioRxiv, 2019 - biorxiv.org
Background There is debate about the value of adding information on genetic and other
molecular markers to conventional cardiovascular disease (CVD) risk predictors. Methods …
molecular markers to conventional cardiovascular disease (CVD) risk predictors. Methods …