In recent years, major advances have been made toward understanding the role of nitric
oxide (NO) in the ischemic biology of the heart. It is now clear that NO, either endogenous or …

Over the past decade, an enormous number of studies (> 100) have focused on the role of
nitric oxide (NO) in myocardial ischemia. It is important to distinguish the function of NO in …

Ischemic preconditioning (PC) is a polygenic defensive cellular adaptive phenomenon
whereby brief ischemic stimuli render the heart resistant to subsequent similar stress. The …

Nitrite, once thought to be an inert biomarker of NO formation, is now recognized as an
endocrine storage pool of bioactive NO. While nitrite mediates a number of hypoxic …

Over a decade of research has shown nitric oxide (NO) to be a ubiquitous modulator of
biological phenomena from cell signal to eVector and from physiology to pathophysiology …

Administration of nitric oxide (NO), NO donors or drugs that enhance NO realease (statins,
calcium antagonists, ACE-inhibitors, dexamethasone) prior to ischemia protects the …

The mammalian heart expresses all three isoforms of nitric oxide synthases (NOS) in diverse
cell types of the myocardium. Despite their apparent promiscuity, the NOS isoforms support …

Reactive oxygen species (ROS) are generated by several different cellular sources, and
their accumulation within the myocardium is widely considered to cause harmful oxidative …

Nitric oxide synthases (NOSs) are a family of enzymes that are responsible for the synthesis
of nitric oxide (NO) from the amino acid L‐arginine in the body. Among the three key NOSs …

Coronary artery reperfusion is widely used to restore blood flow in acute myocardial
infarction and limit its progression. However, reperfusion of ischemic myocardium results in …