[HTML][HTML] Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers

CL Day, NP Seth, M Lucas, H Appel… - The Journal of …, 2003 - Am Soc Clin Investig
Containment of hepatitis C virus (HCV) and other chronic human viral infections is
associated with persistence of virus-specific CD4 T cells, but ex vivo characterization of …

Full-Breadth Analysis of CD8+ T-Cell Responses in Acute Hepatitis C Virus Infection and Early Therapy

GM Lauer, M Lucas, J Timm, K Ouchi, AY Kim… - Journal of …, 2005 - Am Soc Microbiol
Multispecific CD8+ T-cell responses are thought to be important for the control of acute
hepatitis C virus (HCV) infection, but to date little information is actually available on the …

T‐cell response to structural and nonstructural hepatitis C virus antigens in persistent and self‐limited hepatitis C virus infections

C Ferrari, A Valli, L Galati, A Penna, P Scaccaglia… - …, 1994 - Wiley Online Library
Twenty‐nine patients with chronic hepatitis C and 15 asymptomatic hepatitis C virus
antibody–positive subjects who clinically recovered from hepatitis C virus infection were …

Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C

DE Kaplan, K Sugimoto, K Newton, ME Valiga, F Ikeda… - Gastroenterology, 2007 - Elsevier
Background & Aims: Acute hepatitis C virus (HCV) infection becomes chronic in the majority
of patients. Although HCV-specific CD4 T-cell response is associated with HCV clearance …

Presence of functional dendritic cells in patients chronically infected with hepatitis C virus

RS Longman, AH Talal, IM Jacobson, ML Albert… - Blood, 2004 - ashpublications.org
The absence of expanded numbers of hepatitis C virus (HCV)-reactive CD8+ T lymphocytes
(CTLs) in patients chronically infected with HCV has led to the investigation of dendritic cell …

Virus-specific CD4+ T cells have functional and phenotypic characteristics of follicular T-helper cells in patients with acute and chronic HCV infections

B Raziorrouh, K Sacher, RG Tawar, F Emmerich… - Gastroenterology, 2016 - Elsevier
Background & Aims Follicular T-helper (Tfh) cells contribute to pathogen-specific antibody
responses by providing maturation signals to B cells. In mice with viral infections, virus …

Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection.

B Rehermann, KM Chang… - The Journal of …, 1996 - Am Soc Clin Investig
Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes (CTL) are present in the peripheral
blood and liver of chronically infected patients. The current study was performed to study the …

Conserved hepatitis C virus sequences are highly immunogenic for CD4+ T cells: implications for vaccine development

V Lamonaca, G Missale, S Urbani, M Pilli, C Boni… - Hepatology, 1999 - journals.lww.com
The HLA class II-restricted T-cell response to hepatitis C virus (HCV) antigens is believed to
influence the final outcome of hepatitis C, because it is vigorous in patients who recover from …

Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.

G Missale, R Bertoni, V Lamonaca… - The Journal of …, 1996 - Am Soc Clin Investig
The anti-viral T cell response is believed to play a central role in the pathogenesis of
hepatitis C virus infection. Since chronic evolution occurs in> 50% of HCV infections, the …

Determinants of viral clearance and persistence during acute hepatitis C virus infection

R Thimme, D Oldach, KM Chang, C Steiger… - The Journal of …, 2001 - rupress.org
The virological and immunological features of hepatitis C virus (HCV) infection were studied
weekly for 6 months after accidental needlestick exposure in five health care workers, four of …