Increased vascular permeability: a major cause of hypoalbuminaemia in disease and injury

A Fleck, F Hawker, PI Wallace, G Raines, J Trotter… - The Lancet, 1985 - Elsevier
The rate of loss of albumin to the tissue spaces (measured as transcapillary escape rate)
rose by more than 300% in patients with septic shock, and the average increase within 7 h of …

Effects of albumin supplementation on microvascular permeability in septic patients

MP Margarson, NC Soni - Journal of applied physiology, 2002 - journals.physiology.org
Albumin has a stabilizing effect on endothelium and helps maintain capillary permeability to
macromolecules. Critically ill patients with sepsis may have profound hypoalbuminemia, but …

Increased transcapillary escape rate of albumin, IgG, and IgM after plasma volume expansion

HH Parving, N Rossing, SL Nielsen… - American Journal of …, 1974 - journals.physiology.org
MATERIALS AND METHODS Eight healthy male volunteers aged 22-28 years, with a mean
body weight of 73 kg, were investigated. Plasma volume expansion was accomplished in …

Increased urinary albumin-excretion rate in benign essential hypertension

HH Parving, CE Mogensen, PE Evrin - The Lancet, 1974 - Elsevier
The daily urinary albumin-excretion rate was measured by a sensitive radioimmunoassay in
eight normal subjects (average blood-pressure 126/83 mm. Hg), fourteen patients effectively …

Albumin modulation of capillary permeability: test of an adsorption mechanism

VH Huxley, FE Curry - American Journal of Physiology …, 1985 - journals.physiology.org
We investigated further the mechanism whereby albumin interacts with the walls of capillary
blood vessels to maintain normal permeability properties. In individually perfused capillaries …

[HTML][HTML] Clinical use of albumin

P Caraceni, M Tufoni, ME Bonavita - Blood transfusion, 2013 - ncbi.nlm.nih.gov
Human albumin (HA) is the most abundant circulating protein in the plasma of healthy
individuals (3.5-5 g/dL) since it represents approximately 50% of the total protein content …

Transcapillary escape rate of albumin and plasma volume in essential hypertension

HH Parving, F Gyntelberg - Circulation research, 1973 - Am Heart Assoc
The transcapillary escape rate of albumin, the fraction of intravascular mass of albumin that
passes to the extravascular space per unit time, was determined from the disappearance of …

Fluid volume and albumin kinetics occurring with major surgery

RC Hoye, SH Bennett, GW Geelhoed, C Gorschboth - Jama, 1972 - jamanetwork.com
Studies investigating fluid volume dynamics and albumin kinetics in patients undergoing
major abdominal surgery indicate that during the operation, marked deficits develop in the …

Volume expansion and plasma protein clearance during intravenous infusion of 5% albumin and autologous plasma

A Hedin, RG Hahn - Clinical Science, 2005 - portlandpress.com
Autologous plasma may be used to replace plasma volume and plasma proteins during
surgery, but its effectiveness is largely unknown. In the present study, the characteristics of …

Transcapillary escape rate of albumin positively correlates with plasma albumin concentration in acute but not in chronic inflammatory disease

PE Ballmer, AF Ochsenbein, S Schütz-Hofmann - Metabolism, 1994 - Elsevier
The relationship among “negative” plasma acute-phase proteins (APP), ie, albumin,
prealbumin, and transferrin, and “positive” APP, ie, C-reactive protein (CRP), fibrinogen, and …