Type 1 diabetes (T1DM) affects one in every 400 children and adolescents in the US. Due to
the limitations of exogenous insulin therapy and whole pancreas transplantation, pancreatic …

Islet transplantation is a promising alternative therapy for insulin-dependent patients, with
the potential to eliminate life-threatening hypoglycemic episodes and secondary …

Type 1 diabetes was a life-long disease that affected numerous people around the world.
Insulin therapy has its limitations that may involve hyperglycemia and heavy burden of …

Biofunctionalized polyethylene glycol maleimide (PEG–MAL) hydrogels were engineered as
a platform to deliver pancreatic islets to the small bowel mesentery and promote graft …

Islets transplantation is a promising treatment for type 1 diabetes mellitus. However, severe
host immune rejection and poor oxygen/nutrients supply due to the lack of surrounding …

The use of immunoisolating macrodevices in islet transplantation confers the benefit of
safety and translatability by containing transplanted cells within a single retrievable device …

Islet transplantation offers a promising treatment for type 1 diabetes (T1D). However, a major
hurdle in this treatment is the rapid loss of functional islets during culture and after …

Pancreatic islet transplantation is a promising treatment for type 1 diabetes. However,
viability and functionality of the islets after transplantation are limited due to loss of integrity …

The transplantation of allogeneic islets in recent clinical trials has shown substantial promise
as a therapy for type 1 diabetes; however, long-term insulin independence remains …

Lack of rapid revascularization and inflammatory attacks at the site of transplantation
contribute to impaired islet engraftment and suboptimal metabolic control after clinical islet …