Background Endothelial cell (EC) dysfunction contributes to hypertension and mechanisms
of atherosclerosis. Agents that improve EC function may provide vascular protection …

Diabetes is associated with alterations in nitric oxide–mediated vasomotor function. The role
of nitric oxide generated via the neuronal nitric oxide synthase pathway in the control of …

Nitric oxide (NO) plays an important role in the regulation of vascular tone, and evidence
suggests that endothelial-dependent relaxation, possibly mediated via NO, is impaired in …

Nitric oxide (NO) is a potent regulator in the cardiovascular system; it is generated by the
nitric oxide synthase (NOS) family of proteins. NO produced in endothelial cells plays a …

To evaluate the role of nitric oxide (NO) in diabetic hyperfiltration, renal hemodynamic
changes and changes in urinary excretion of NO2/NO3 in response to the NO inhibitor nitro-l …

Altered vasoreactivity may contribute significantly to the pathogenesis of diabetic vascular
complications. This study investigated the effect of (a) insulin‐treated diabetes, and (b) …

Objective: A decreased responsiveness to endothelium-dependent vasodilatory substances
is characteristically seen in isolated arteries from spontaneously hypertensive rats (SHR) …

Objectives To examine the role of endogenous nitric oxide (NO) in the pathogenesis of
hypertension and insulin resistance in chronic hyperinsulinemic rats. Methods Sustained …

Objective Diabetes mellitus is associated with increased incidence of cardiovascular
complications. Lack of nitric oxide production may exacerbate these complications. We …

1. The present study was performed to determine the relationship between diabetic
glomerular hyperfiltration and nitic oxide as modulated by the chronic administration of l …