Identification of neuronal pentraxins as synaptic binding partners of C1q and the involvement of NP1 in synaptic pruning in adult mice
RÁ Kovács, H Vadászi, É Bulyáki, G Török… - Frontiers in …, 2021 - frontiersin.org
Elements of the immune system particularly that of innate immunity, play important roles
beyond their traditional tasks in host defense, including manifold roles in the nervous …
beyond their traditional tasks in host defense, including manifold roles in the nervous …
Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning
C1q, a member of the immune complement cascade, is implicated in the selective pruning of
synapses by microglial phagocytosis. C1q-mediated synapse elimination has been shown …
synapses by microglial phagocytosis. C1q-mediated synapse elimination has been shown …
Neuronal pentraxin 1 negatively regulates excitatory synapse density and synaptic plasticity
J Figueiro-Silva, A Gruart, KB Clayton… - Journal of …, 2015 - Soc Neuroscience
In mature neurons, the number of synapses is determined by a neuronal activity-dependent
dynamic equilibrium between positive and negative regulatory factors. We hypothesized that …
dynamic equilibrium between positive and negative regulatory factors. We hypothesized that …
Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-β and is overexpressed in dystrophic neurites in Alzheimer's brain
MA Abad, M Enguita… - Journal of …, 2006 - Soc Neuroscience
Accumulation of amyloid-β (Aβ) is thought to play a central role in the progressive loss of
synapses, the neurite damage, and the neuronal death that are characteristic in brains …
synapses, the neurite damage, and the neuronal death that are characteristic in brains …
Complement system in neural synapse elimination in development and disease
J Presumey, AR Bialas, MC Carroll - Advances in immunology, 2017 - Elsevier
Recent discoveries implicate the classical complement cascade in normal brain
development and in disease. Complement proteins C1q, C3, and C4 participate in synapse …
development and in disease. Complement proteins C1q, C3, and C4 participate in synapse …
The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration
Complement overactivation mediates microglial synapse elimination in neurological
diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but how …
diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but how …
Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease
QL Ma, E Teng, X Zuo, M Jones, B Teter, EY Zhao… - Neurobiology of …, 2018 - Elsevier
Synaptic neurodegeneration is thought to be an early event initiated by soluble β-amyloid
(Aβ) aggregates that closely correlates with cognitive decline in Alzheimer disease (AD) …
(Aβ) aggregates that closely correlates with cognitive decline in Alzheimer disease (AD) …
Contribution of Neurons and Glial Cells to Complement‐Mediated Synapse Removal during Development, Aging and in Alzheimer's Disease
C Luchena, J Zuazo-Ibarra, E Alberdi… - Mediators of …, 2018 - Wiley Online Library
Synapse loss is an early manifestation of pathology in Alzheimer's disease (AD) and is
currently the best correlate to cognitive decline. Microglial cells are involved in synapse …
currently the best correlate to cognitive decline. Microglial cells are involved in synapse …
The double-edged flower: roles of complement protein C1q in neurodegenerative diseases
AJ Tenner, MI Fonseca - Current topics in complement, 2006 - Springer
C1q, the recognition component of the classical complement activation pathway, is a
multifunctional protein of the immune system that has been shown to be expressed in the …
multifunctional protein of the immune system that has been shown to be expressed in the …
[HTML][HTML] Insight into the role of phosphatidylserine in complement-mediated synapse loss in Alzheimer's disease
The innate immune system plays an integral role in the brain. Synaptic pruning, a
fundamental process in developmental circuit refinement, is partially mediated by …
fundamental process in developmental circuit refinement, is partially mediated by …
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