Direct Gαq gating is the sole mechanism for TRPM8 inhibition caused by bradykinin receptor activation
X Zhang - Cell reports, 2019 - cell.com
Activation of Gα q-coupled receptors by inflammatory mediators inhibits cold-sensing
TRPM8 channels, aggravating pain and inflammation. Both Gα q and the downstream …
TRPM8 channels, aggravating pain and inflammation. Both Gα q and the downstream …
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain
The subjective feeling of cold is mediated by the activation of TRPM8 channels in
thermoreceptive neurons by cold or by cooling agents such as menthol. Here, we …
thermoreceptive neurons by cold or by cooling agents such as menthol. Here, we …
TRPM channels in human diseases
The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …
mGluR6 deletion renders the TRPM1 channel in retina inactive
In darkness, glutamate released from photoreceptors activates the metabotropic glutamate
receptor 6 (mGluR6) on retinal ON bipolar cells. This activates the G protein Go, which then …
receptor 6 (mGluR6) on retinal ON bipolar cells. This activates the G protein Go, which then …
Structural mechanism of TRPM7 channel regulation by intracellular magnesium
E Schmidt, C Narangoda, W Nörenberg… - Cellular and Molecular …, 2022 - Springer
Abstract Zn2+, Mg2+ and Ca2+ are essential divalent cations implicated in many metabolic
processes and signalling pathways. An emerging new paradigm is that the organismal …
processes and signalling pathways. An emerging new paradigm is that the organismal …
TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations
WL Wei, HS Sun, ME Olah, X Sun… - Proceedings of the …, 2007 - National Acad Sciences
Exposure to low Ca2+ and/or Mg2+ is tolerated by cardiac myocytes, astrocytes, and
neurons, but restoration to normal divalent cation levels paradoxically causes Ca2+ …
neurons, but restoration to normal divalent cation levels paradoxically causes Ca2+ …
Promiscuous G-protein-coupled receptor inhibition of transient receptor potential melastatin 3 ion channels by Gβγ subunits
O Alkhatib, R da Costa, C Gentry, T Quallo… - Journal of …, 2019 - Soc Neuroscience
Transient receptor potential melastatin 3 (TRPM3) is a nonselective cation channel that is
inhibited by Gβγ subunits liberated following activation of Gαi/o protein-coupled receptors …
inhibited by Gβγ subunits liberated following activation of Gαi/o protein-coupled receptors …
TRPM3 in brain (patho) physiology
K Held, BI Tóth - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Already for centuries, humankind is driven to understand the physiological and pathological
mechanisms that occur in our brains. Today, we know that ion channels play an essential …
mechanisms that occur in our brains. Today, we know that ion channels play an essential …
Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition
Abstract The Ca2+-activated TRPM5 channel plays essential roles in taste perception and
insulin secretion. However, the mechanism by which Ca2+ regulates TRPM5 activity …
insulin secretion. However, the mechanism by which Ca2+ regulates TRPM5 activity …
Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC) 4 and TRPC5 channels
The ubiquitous transient receptor potential canonical (TRPC) channels function as non-
selective, Ca 2+-permeable channels and mediate numerous cellular functions. It is …
selective, Ca 2+-permeable channels and mediate numerous cellular functions. It is …